Browsing by Author "Botelho, Monica C."
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- CarcinogenesisPublication . Botelho, Monica C.Cancer, or neoplasia, is a complex disease with multiple causes. Many intrinsic and extrinsic factors influence the development of cancer. Intrinsic or host factors include age, sex, genetic constitution, immune system function, metabolism, hormone levels, and nutritional status. Extrinsic factors include substances eaten, drunk, or smoked; workplace and environmental (air, water, and soil) exposures; natural and medical radiation exposure; sexual behavior; elements of lifestyle such as social and cultural environment, personal behavior, and habits; and infection with bacteria such as chronic cystitis, virus like Epstein Barr and Hepatitis B and C virus and parasites including Schistosoma haematobium, Opisthorchis viverrini, and Clonorchis sinensis. Intrinsic and extrinsic factors can interact with one another to influence the development of cancer. In this article, we will discuss all the varied aspects of research that will ultimately lead to the prevention of cancer in man.
- Conditioned medium from MCF-7 breast cancer cells induces phenotypic carcinogenesis in HCV29 normal bladder cellsPublication . Luís, Carla; Fernandes, Rúben; Soares, Raquel; Botelho, Monica C.Main goal: since MCF-7 cells release CEQ, the aim is to investigate the role of breast cancer conditioned medium as tumor initiator of normal bladder urothelial cells.
- Editorial: Parasites and CancerPublication . Botelho, Monica C.; Richter, JoachimEmerging evidence indicates that certain parasites such as the blood fluke Schistosoma haematobium, and small liver flukes Opisthorchis viverrini and Clonorchis sinensis are causative agents of malignancies such as bladder cancer caused bv schistosomes and cholangiocarcinoma by liver flukes. In many endemic regions these helminths are responsible for the majority of cancer cases. Parasites, other than helminths, are also associated with cancers, such as Theileria, an intracellular eukaryotic parasite. On the contrary, some parasite infections or molecules seem to display protective effects on some cancers, such as is the case with Echinococcus. Therefore, understanding how these parasites cause/promote or hinder oncogenesis in humans will aid to develop novel strategies for controlling the parasitosis and for preventing and treating the infection-associated malignancy. The Infectious Diseases—Surveillance, Prevention, and Treatment section of the journal Frontiers in Medicine, in partnership with the journal Frontiers in Public Health, hosted the first Research Topic on Parasites and Cancer with the aim to facilitate global parasites infectionassociated cancer elimination through scientific advances. Nearly 40 authors, representatives from Australia, Brazil, Ethiopia, Germany, Portugal, United States, and Thailand, participated in this Research Topic covering all continents of the world. Some of these authors are the most cited in the field of parasites and cancer: Ross H. Andrews, Paul Brindley, Michael H. Hsieh, Alex Loukas, Donald McManus, Trevor N. Petney, Paiboon Sithithaworn, and Puangrat Yongvanit. (...)
- Estrogen metabolism in Schistosoma haematobium - associated bladder cancerPublication . Botelho, Monica C.Outline: 1.Schistosomes - Facts and figures; 2. Cancer-associated schistosomiasis - Estrogen and Estrogen Receptor signaling; 3. Infertility-associated schistosomiasis - Hormonal imbalance induced by schistosomes.
- Halting Schistosoma haematobium - Associated Bladder CancerPublication . Botelho, Monica C.; Alves, Helena; Joachim, RichterBackground: At present schistosomiasis is endemic in 78 countries, affecting more than 260 million people. Schistosomiasis haematobia alone affects more than 112 millions. Evidence Acquisition: We performed a computerized search of in PubMed database with keywords: Bladder Cancer Cost and Schistosomiasis Mass Treatment. Results: Bladder cancer is an important sequelae of this infection. In low-resource countries, where this disease is endemic, individuals inflicted with bladder cancer have very limited access to treatment and death is most probably certain. Conclusions: Mass treatment with praziquantel is an easy, safe, and inexpensive treatment that could save the lives of thousands and reduce the morbidity of millions.
- Pathways of estrogen metabolism underlying the association between Schistosoma haematobium and bladder cancerPublication . Gonçalves, Ana Rita; Luis, Carla; Soares, Raquel; Fernandes, Ruben; Botelho, Monica C.Communication on pathways of estrogen metabolism underlying the association between Schistosoma haematobium and bladder cancer.
- Schistosomiasis and infertility: what do we know?Publication . Ribeiro, Ana Rita; Luis, Carla; Fernandes, Ruben; Botelho, Monica C.There is increasing attention on the complex interactions occurring between schistosome parasites and their hosts. However, little is known about the occurrence, epidemiology, and mechanisms of schistosomiasis-associated infertility. In this article, we argue that an in-depth understanding of the interplay between parasites and the host endocrine system may significantly enhance current knowledge of infertility in infected individuals. We discuss the basic hormonal mechanisms that may lead to the discovery of entirely novel anthelmintic interventions against schistosomiasis.
- The cancer hygiene hypothesis: from theory to therapeutic helminthsPublication . Fernandes, Ruben; Alves, Helena; Botelho, Monica C.The “Hygiene Hypothesis” was postulated by David Strachan in 1989 to explain for the rapid 20th century increase in allergic diseases such as asthma. In this hypothesis, children from developed countries living in ultra-hygienic environments and avoiding exposure to viruses, bacteria, and parasites, especially helminthes, have an increased risk of atopic disorders.