Browsing by Author "Bessa, M.J."
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- Cytotoxic effects of hydro-ethanolic extracts from Coleostephus myconis (L.) rchb.f. flowers and green partsPublication . Bessada, Silvia; Barreira, J.C.M.; Costa, C.; Bessa, M.J.; Teixeira, J.P.; Oliveira, M.B.P.P.The species Coleostephus myconis (L.) Rchb.f. is considered as being a harmful and persistent weed, with constant presence in abandoned farmland. Prevailing in the Portuguese flora, C. myconis belongs to the Asteraceae family, which is recognized for its global medicinal value and high antioxidant power, as described in different research works. Nevertheless, before considering incorporating this species in food of pharmaceutical applications, it is imperative to evaluate their potential toxicity.
- Cytotoxicity and antibacterial activity of polar extracts obtained from saffron (Crocus sativus L.) Floral bio-residuesPublication . Barreira, João; Costa, C.; Branquinho, R.; Rebelo, J.M.; Bessa, M.J.; Peixe, L.; Teixeira, J.P.; Oliveira, M.B.P.P.Saffron (Crocus sativus L.) flower comprises six purple tepals, three yellow stamens and a white filiform style ending in a stigma with three threads, which represents less than 10% (w/w) of the flower weight. However, the stigma is the dominant reason to farm/harvest saffron, since it represents the most valued spice (after being dried). Interesting large amounts of floral bio-residues are produced and wasted from this action, considering that a single kg of saffron spice generates ~63 kg of floral bioresidues. This scenario creates opportunities for the extended use of this discarded material, particularly owing to its important bioactive compounds and related health promoting properties, such as antioxidant, antityrosinase, antidepressant, antifungal, antinociceptive, anti-inflammatory and arterial pressure reduction.
- In vitro toxicity of TiO2 nanoparticles immobilized on clay to human hepatic cellsPublication . Bessa, M.J.; Reinosa, J.J; Fernández, J.F.; Bañares, M.; Teixeira, J.P.; Costa, CObjective: Evaluate in vitro toxicity of TiO2 nanoparticles immobilized on clay (C-TiO2) in a hepatocellular carcinoma human cell line (HepG2) as well as of its single elements.
- In vitro toxicity screening of silica-coated superparamagnetic iron oxide nanoparticles in glial cellsPublication . Costa, Carla; Brandão, F.; Bessa, M.J.; Costa, S.; Valdiglesias, V.; Kiliç, G.; Fernández-Bertólez, N.; Pásaro, E.; Laffon, B.; Teixeira, João PauloNanotechnology industry is progressing with prospects of substantial benefits to economics and science. Superparamagnetic iron oxide nanoparticles (ION) have been showing excellent magnetic properties, biocompatibility and biodegradability, broadening their potential applications and importance in the biomedical field
- Insights into the role of the physicochemical properties in the toxicity of SiO2 nanoparticles in rat alveolar epithelial RLE-6TN cellsPublication . Brandão, M.F.P.; Bessa, M.J.; Costa, C.; Fraga, S.; Haase, A.; Teixeira, J.P.Silica nanoparticles (SiO2 NPs) are easily produced in different sizes and surface modifications enabling their use in several industrial and biomedical applications, which increases the risk of human exposure to these nanoparticles. Because the toxicological profile of nanoparticles is dependent upon their physicochemical properties, the aim of this study was to investigate the influence of the physicochemical properties (size, surface capping and hydrophilicity/hydrophobicity) in the cyto- and genotoxicity of SiO2 NPs in rat alveolar epithelial cells (RLE-6TN), a primary target during inhalation exposure.