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- In vitro toxicity of TiO2 nanoparticles immobilized on clay to human hepatic cellsPublication . Bessa, M.J.; Reinosa, J.J; Fernández, J.F.; Bañares, M.; Teixeira, J.P.; Costa, CObjective: Evaluate in vitro toxicity of TiO2 nanoparticles immobilized on clay (C-TiO2) in a hepatocellular carcinoma human cell line (HepG2) as well as of its single elements.