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Publication
Seroprevalência de SARS-CoV-2 em profissionais de saúde de hospitais em comparação com a população geral, 2021-2022
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Advisor(s)
Abstract(s)
Os profissionais de saúde (PS) desempenham um papel essencial na linha de frente durante emergências de saúde causadas por doenças infeciosas.
Protegê-los é crucial para garantir a sua saúde, manter a continuidade do atendimento aos pacientes e prevenir a transmissão durante a prestação de cuidados. Este estudo teve como objetivo estimar a tendência da seroprevalência de SARS-CoV-2 entre PS de uma coorte hospitalar entre maio de 2021 e junho de 2022 e compará-la com a tendência de seroprevalência na população geral com 40-49 anos. Adicionalmente, foi feita a caracterização dos PS de acordo com o seu estado de seropositividade relativa aos anticorpos IgG anti-nucleocapside (IgG Anti-N).
No âmbito de um estudo da efetividade das vacinas, os PS foram testados para deteção de anticorpos IgG anti-RBD/Spike contra o SARS-CoV-2 em três períodos: maio-junho de 2021, setembro-novembro de 2021 e maio-junho de 2022. No terceiro momento, também foram avaliados anticorpos IgG Anti-N. Para comparação com a população geral, foram usados os resultados de três fases do Inquérito Serológico Nacional à COVID-19 (ISN COVID-19): fevereiro-março de 2021, setembro-novembro de 2021 e abril-junho de 2022.
Um total de 977, 509 e 67 PS foram testados nos três momentos, com uma seroprevalência de 85%, 89% e 100%, respetivamente. Essas taxas foram semelhantes às encontradas na população geral portuguesa, exceto no primeiro período (85% versus 19% na população geral, grupo etário 40-49 anos). No terceiro momento, a seroprevalência pós-infeção (anticorpos IgG anti-nucleocápside) foi maior entre os PS do que na população geral (41% versus 27%). A idade menor e o contacto direto com pacientes com COVID-19 estavam associados à positividade para os anticorpos IgG anti-N.
A tendência crescente da seroprevalência nos PS segue a mesma tendência observada na população geral. Embora os períodos não coincidam exatamente, no 1º momento, a seroprevalência para SARS-CoV-2 mais elevada entre os PS esteve provavelmente associada à vacinação prioritária desse grupo. No 3º momento, a maior seroprevalência pós-infeção entre os PS indica um aumento na exposição e incidência de infeção nesse grupo após a onda da variante Ômicron. Considerando a diminuição da cobertura vacinal contra a COVID-19 entre os PS, é essencial continuar a monitorização da seroprevalência e a incidência de infeção por COVID-19 neste grupo.
Healthcare workers (HCWs) are essential as front line responders during health emergencies caused by infectious diseases. Protecting them is crucial to ensure their health, maintain continuous patient care, and prevent transmission to patients. This study aimed to estimate the SARS-CoV-2 seroprevalence trend among HCWs from a Portuguese hospital cohort between May 2021 and July 2022 and to compare it with the seroprevalence trend in the general population aged 40-49 years. Additionally, the characterization of HCWs with seroconversion was performed based on their positivity for anti-nucleocapsid (Ant i-N) IgG antibodies. In the ambit of a vaccine effectiveness study, HCWs were screened for ant i-RBD/Spike IgG ant ibodies against SARS-CoV-2 in 3 moments: May-Jul2021, Sept-Nov2021, and May-Jun2022. At the last moment, Ant i-N IgG antibodies were also assessed. To compare with data on the general population, we used results from three national serological surveys (NSS) phases: Feb-March 2021; Sept-Nov2021; April-Jun2022. A total of 977, 509 and 67 HCWs were screened in the 3 moments, and the SARS-CoV-2 seroprevalence was 85%, 89%, and 100%, respectively. These seroprevalences were similar to those found in the Portuguese general population, except for the 1st period (85% versus 18.8% in the general population, age group 40-49). At the last moment, the post-infection seroprevalence (anti-N IgG antibodies) was higher among HCWs than in the general population (41% versus 27%). A lower age and direct contact with COVID-19 patients were associated with anti-N IgG antibody positivity. The increasing trend of seroprevalence among HCWs follows the same trend in the general population. Although the periods are not exactly coincident, in the 1st moment, higher SARS-CoV-2 seroprevalence was probably linked to priority vaccine uptake. In the 3rd moment, the higher post-infection seroprevalence among HCWs suggests a raised exposure and infection incidence in HCWs following the Omicron wave. Considering the decrease in COVID-19 vaccination coverage among HCWs, it is essential to continue monitoring seroprevalence and COVID-19 infection in this group.
Healthcare workers (HCWs) are essential as front line responders during health emergencies caused by infectious diseases. Protecting them is crucial to ensure their health, maintain continuous patient care, and prevent transmission to patients. This study aimed to estimate the SARS-CoV-2 seroprevalence trend among HCWs from a Portuguese hospital cohort between May 2021 and July 2022 and to compare it with the seroprevalence trend in the general population aged 40-49 years. Additionally, the characterization of HCWs with seroconversion was performed based on their positivity for anti-nucleocapsid (Ant i-N) IgG antibodies. In the ambit of a vaccine effectiveness study, HCWs were screened for ant i-RBD/Spike IgG ant ibodies against SARS-CoV-2 in 3 moments: May-Jul2021, Sept-Nov2021, and May-Jun2022. At the last moment, Ant i-N IgG antibodies were also assessed. To compare with data on the general population, we used results from three national serological surveys (NSS) phases: Feb-March 2021; Sept-Nov2021; April-Jun2022. A total of 977, 509 and 67 HCWs were screened in the 3 moments, and the SARS-CoV-2 seroprevalence was 85%, 89%, and 100%, respectively. These seroprevalences were similar to those found in the Portuguese general population, except for the 1st period (85% versus 18.8% in the general population, age group 40-49). At the last moment, the post-infection seroprevalence (anti-N IgG antibodies) was higher among HCWs than in the general population (41% versus 27%). A lower age and direct contact with COVID-19 patients were associated with anti-N IgG antibody positivity. The increasing trend of seroprevalence among HCWs follows the same trend in the general population. Although the periods are not exactly coincident, in the 1st moment, higher SARS-CoV-2 seroprevalence was probably linked to priority vaccine uptake. In the 3rd moment, the higher post-infection seroprevalence among HCWs suggests a raised exposure and infection incidence in HCWs following the Omicron wave. Considering the decrease in COVID-19 vaccination coverage among HCWs, it is essential to continue monitoring seroprevalence and COVID-19 infection in this group.
Description
Keywords
SARS-CoV-2 Seroprevalência Profissionais de Saúde Efetividade das Vacinas Cuidados de Saúde
Pedagogical Context
Citation
Boletim Epidemiológico Observações. 2025 maio-agosto;14(38): 53-57
Publisher
Instituto Nacional de Saúde Doutor Ricardo Jorge, IP