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Advisor(s)
Abstract(s)
O arsénio é um elemento naturalmente presente no meio ambiente e que
também pode ser libertado em resultado de atividades antropogénicas,
podendo encontrar-se na forma de compostos orgânicos ou inorgânicos.
O arsénio é considerado pela Organização Mundial de Saúde como
um dos dez químicos de maior preocupação para a saúde pública, uma
vez que o arsénio e os compostos inorgânicos de arsénio estão classificados
como cancerígenos pela Agência Internacional para a Investigação
do Cancro. A exposição a arsénio inorgânico ocorre principalmente
por via alimentar, através do consumo de água e de alimentos contaminados.
Em Portugal são escassos os dados sobre a exposição a arsénio
na população geral, pelo que o objetivo do presente estudo é a caracterização
da exposição da população adulta portuguesa a arsénio,
utilizando amostras de urina colhidas num estudo populacional nacional
( INSEF-ExpoQuim). O presente trabalho incluiu 171 participantes no estudo
INSEF-ExpoQuim que forneceram uma amostra de urina para análise
da concentração de arsénio total por espectrometria de massa com
plasma indutivo acoplado ( ICP-MS ). Observou-se uma média geométrica
de 47,1 μg As/L [ IC95%: 41,4-53,5 ] e 8,8% dos indivíduos apresentavam
valores de arsénio considerados elevados. Não se observaram diferenças
nos níveis de arsénio por sexo, grupo etário, grau de urbanização da
área de residência, nível de escolaridade e situação face ao trabalho. Os
resultados preliminares obtidos apontam para a necessidade de monitorização
dos níveis de arsénio na população portuguesa.
Arsenic is an element naturally present in the environment, but it can also be released as a result of anthropogenic activities. In the environment, arsenic can be found in the form of organic compounds and in the form of inorganic compounds. Arsenic is considered by the World Health Organization as one of the ten chemicals of greatest concern for public health, since arsenic and inorganic arsenic compounds are classified as carcinogenic by the International Agency for Research on Cancer. Exposure to inorganic arsenic occurs mainly through food, through consumption of contaminated water and food. In Portugal, data on arsenic exposure in the general population are scarce, so the aim of the present study was to characterize the exposure of the Portuguese adult population to arsenic, using urine samples collected in a national population study ( INSEF-ExpoQuim). The present work included 171 participants in the INSEF-ExpoQuim study who provided a urine sample for analysis of total arsenic concentration by inductively coupled plasma mass spectrometry (ICP-MS). A geometric mean of 47.1 μg As/L [ 95% CI: 41.4-53.5 ] was observed and 8.8% of the individuals had arsenic levels considered high. No differences were observed in arsenic levels by sex, age group, degree of urbanization of the area of residence, educational level and employment situation. The obtained preliminary results point to the need to monitor the levels of arsenic in the Portuguese population.
Arsenic is an element naturally present in the environment, but it can also be released as a result of anthropogenic activities. In the environment, arsenic can be found in the form of organic compounds and in the form of inorganic compounds. Arsenic is considered by the World Health Organization as one of the ten chemicals of greatest concern for public health, since arsenic and inorganic arsenic compounds are classified as carcinogenic by the International Agency for Research on Cancer. Exposure to inorganic arsenic occurs mainly through food, through consumption of contaminated water and food. In Portugal, data on arsenic exposure in the general population are scarce, so the aim of the present study was to characterize the exposure of the Portuguese adult population to arsenic, using urine samples collected in a national population study ( INSEF-ExpoQuim). The present work included 171 participants in the INSEF-ExpoQuim study who provided a urine sample for analysis of total arsenic concentration by inductively coupled plasma mass spectrometry (ICP-MS). A geometric mean of 47.1 μg As/L [ 95% CI: 41.4-53.5 ] was observed and 8.8% of the individuals had arsenic levels considered high. No differences were observed in arsenic levels by sex, age group, degree of urbanization of the area of residence, educational level and employment situation. The obtained preliminary results point to the need to monitor the levels of arsenic in the Portuguese population.
Description
Keywords
Arsénio Exposição Humana Biomonitorização Humana Saúde Ambiental Avaliação do Risco INSEF-ExpoQuim Exposição da População Portuguesa a Químicos Ambientais Genotoxicidade Ambiental Portugal
Pedagogical Context
Citation
Boletim Epidemiológico Observações. 2022;11(Supl 14):25-30
Publisher
Instituto Nacional de Saúde Doutor Ricardo Jorge, IP
