4th International Conference on Food Contaminants (ICFC) 2021: Challenges on early-life exposure: Book of abstracts

Vasco, E.; Martins, C.; Serrenho, I.; Assunção, R.; Alvito, P.

http://hdl.handle.net/10400.18/7795

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(...) Exposure to hazardous chemicals during first 1000 days of life has been linked to an increased risk of a number of health disorders.There is growing evidence that early-life exposure to chemical hazards can lead to non-communicable diseases (NCDs) in adulthood including cancer, diabetes, obesity and auto-immune diseases. Because cells are rapidly dividing and organ systems are developing during childhood and adolescence, exposure to carcinogens during these early life stages is a major risk factor for cancer later in life. Exposure during early-life due to food ingestion of toxic chemicals seems to have a critical role on the rapid epidemiological rise of obesity as well as a trans-generational transmission of risk of later obesity. Some reports provide evidence of a link between early-life adverse events (ELAE)-induced intestinal barrier disruption, inflammation, epigenetic modifications, and the occurrence of late metabolic disorders (MD), including obesity and type 2 diabetes (T2D). Changes in neurobehavior, sexual development, the prevalence of asthma and allergy, among others, have shown to be associated with chemical contaminants exposure at early-life stages. Early-life is a critical sensitive window of susceptibility. Therefore, this conference will aim to gather research scientists, health and food professionals, regulatory entities, and students to discuss different perspectives on this particular period of life in order to debate i) the risks associated with exposing vulnerable populations to chemicals, in particular, food contaminants and ii) toxic effects of early-life exposure to chemicals. This conference is promoted within the framework of the earlyMYCO national project, funded by the Foundation for Science and Technology (FCT), Portugal, aiming to assess the impact of early-life exposure to mycotoxins and their potential impact on human health. (...)