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Publication
Biomonitorização humana de micotoxinas no âmbito do projeto HBM4EU: um estudo sobre desoxinivalenol e fumonisina B1
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Advisor(s)
Abstract(s)
As micotoxinas são toxinas naturais produzidas por fungos, apresentando
efeitos tóxicos para o homem e para os animais. Reconhece-se,
atualmente, que as alterações climáticas terão impacto na distribuição
geográfica de algumas espécies de fungos produtores de micotoxinas o
que se traduzirá, previsivelmente, num aumento da exposição humana a
estes compostos. Pelas razões descritas, urge conhecer a atual exposição
a micotoxinas na Europa, com vista à sua futura monitorização e
à prevenção/redução do seu impacto na saúde. No âmbito da Iniciativa
Europeia em Biomonitorização Humana (HBM4EU) consideraram-se as
micotoxinas desoxinivalenol (DON) e fumonisina B1 (FB1) como substâncias
prioritárias, tendo sido abordadas várias questões relativas à avaliação
da exposição humana e o potencial risco para a saúde. No presente
artigo, apresentam-se as questões identificadas como mais importantes,
respostas obtidas e perspetivas futuras. Os resultados confirmaram
a exposição humana a DON, tendo sido obtidos, pela primeira vez,
dados harmonizados de exposição ao nível europeu e derivado um valor
de referência para essa exposição. Foi ainda proposto, pela primeira vez
no HBM4EU, uma sucessão de eventos biológicos baseados no mecanismo
de ação da FB1 que permitiu associar a exposição durante a gravidez
ao desenvolvimento de defeitos do tubo neural no feto. Espera-se
que estes resultados possam contribuir para uma futura monitorização
da exposição a micotoxinas na Europa e para melhorar a avaliação de
risco destas substâncias.
Mycotoxins are natural low-molecular-weight toxins produced by fungal species that can be toxic for humans and animals. Under the climate change scenario, some fungal species might shift their geographical distribution in response to global warming, leading to changes in the pattern of mycotoxin occurrence and, thus, increasing the risk of human mycotoxin exposure. For this reason, it urges to assess the current human exposure to mycotoxins in Europe, to monitor internal exposure and prevent future health impact. The European Human Biomonitoring Initiative (HBM4EU), running from 2017 to 2022, was set to generate knowledge on internal exposure and their potential health impacts. Within this initiative, the mycotoxins deoxynivalenol (DON) and fumonisin B1 ( FB1) were considered as priority substances to be studied and several policy questions were addressed concerning their risk assessment. The present paper presents policy questions identified within HBM4EU for these mycotoxins, answers obtained and future perspectives. The exposure of the general European population to DON was confirmed using new harmonized data and a reference guidance value for human biomonitoring was set for the first time. Additionaly, an adverse outcome pathway for neural tube defects was proposed for FB1 for the first time. Hopefully these findings may contribute to a more accurate risk assessment of European population´s exposure to mycotoxins.
Mycotoxins are natural low-molecular-weight toxins produced by fungal species that can be toxic for humans and animals. Under the climate change scenario, some fungal species might shift their geographical distribution in response to global warming, leading to changes in the pattern of mycotoxin occurrence and, thus, increasing the risk of human mycotoxin exposure. For this reason, it urges to assess the current human exposure to mycotoxins in Europe, to monitor internal exposure and prevent future health impact. The European Human Biomonitoring Initiative (HBM4EU), running from 2017 to 2022, was set to generate knowledge on internal exposure and their potential health impacts. Within this initiative, the mycotoxins deoxynivalenol (DON) and fumonisin B1 ( FB1) were considered as priority substances to be studied and several policy questions were addressed concerning their risk assessment. The present paper presents policy questions identified within HBM4EU for these mycotoxins, answers obtained and future perspectives. The exposure of the general European population to DON was confirmed using new harmonized data and a reference guidance value for human biomonitoring was set for the first time. Additionaly, an adverse outcome pathway for neural tube defects was proposed for FB1 for the first time. Hopefully these findings may contribute to a more accurate risk assessment of European population´s exposure to mycotoxins.
Description
Baseado no artigo publicado:
Alvito P, A ssunção RM, Bajard L, Mar tins C, Mengelers M, Hans Mol,
Van den Brand A, Namorado S, Vasco E, Viegas S, Silva M. Current
advances, research needs and gaps in Mycotoxins Biomonitoring
under HBM4EU – lessons learned and future t rends. Toxins (Basel ).
2022;14(12):826. https://doi.org/10.3390/toxins14120826
Ficheiro substituído a 2023-02-27, retificação das referências bibliográficas.
Ficheiro substituído a 2023-02-27, retificação das referências bibliográficas.
Keywords
Micotoxinas Desoxinivalenol Fumonisina B1 Biomonitorização Humana HBM4EU Iniciativa Europeia em Biomonitorização Humana Saúde Ambiental Europa Portugal Genotoxicidade Ambiental Segurança Alimentar Toxicologia Avaliação do Risco Exposição Humana
Pedagogical Context
Citation
Boletim Epidemiológico Observações. 2022;11(Supl 14):11-18
Publisher
Instituto Nacional de Saúde Doutor Ricardo Jorge, IP