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Mixtures Toxicology: Mycotoxins in food as a case study

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dc.contributor.authorSilva, M.J.
dc.contributor.authorAlvito, P.
dc.date.accessioned2017-03-15T15:56:50Z
dc.date.available2017-03-15T15:56:50Z
dc.date.issued2016-06
dc.descriptionInvited lecture
dc.description.abstractHistorically, the potential health impact associated to human exposure to chemical stressors has been assessed on the basis of single-chemical and single-exposure pathway scenarios. In recent years, the acknowledged co-occurrence of multiple chemical contaminants in food has suggested, however, a change in the paradigm of the hazard identification and characterization, towards understanding the potential combined effects of chemicals. The most well established and conservative model to predict the combined toxicity of chemicals is based on the concept of additivity, advocating that the joint effect of multiple chemicals is the summation of individual effects. Additivity incorporates the concentration addition (CA) model, assuming the same Mode of Action (MoA) and the independent action (IA) model assuming a dissimilar MoA of chemicals in the mixture. Deviations from these models, i.e., interactive effects include synergism, antagonism and more subtle interactions that depend on the actual doses of the mixture components. To illustrate the challenges faced when addressing mixtures toxicology, my presentation will be focused on the combined toxic effects of mycotoxins with the potential to co-occur in food.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia (FCT), Portugal. HERA project (PTDC/SAU-ESA/100107/2008), MYCOMIX project (PTDC/DTP-FTO/0417/2012), CESAM (UID/AMB/50017/2013).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/4670
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.subjectAlimentação e Nutriçãopt_PT
dc.subjectToxicologia de Misturaspt_PT
dc.subjectToxicologiapt_PT
dc.titleMixtures Toxicology: Mycotoxins in food as a case studypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-FTO%2F0417%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAMB%2F50017%2F2013/PT
oaire.citation.conferencePlacePorto, Portugalpt_PT
oaire.citation.title3rd International Conference on Occupational & Environmental Toxicology (ICOETox)/ 3rd Ibero-American Meeting on Toxicology and Environmental Health (IBAMTox), 21-23 june 2016pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublication7dee8a4a-7112-45ce-a8cb-8c552d7ae061
relation.isProjectOfPublication1d7db62a-6440-4ccb-a5cc-c3f76c8585b3
relation.isProjectOfPublication.latestForDiscovery1d7db62a-6440-4ccb-a5cc-c3f76c8585b3

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