Browsing by Issue Date, starting with "2016-06"
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- Migrant situation in PortugalPublication . Mexia, RicardoShort presentation on the migrant health situation in Portugal
- Avaliação Externa da Qualidade em Microbiologia de Areias de Praias - Estudo PilotoPublication . Faria, Ana Paula; Correia, Helena; Silva, Susana Pereira; Brito, Cristina; Clemente, Vera; Cardoso, Ana; Veríssimo, Cristina; Sabino, Raquel; Simões, Helena; Rodrigues, Raquel; Silva, Cecília; Ferreira, Filipa; Brandão, JoãoAs areias das praias contêm por vezes microrganismos nocivos para a saúde humana, frequentemente em superiores às que existem na água. Atualmente (Brandão et al. 2002; Sabino et al. 2012; Solo-Gabriele et al. 2015) não existe regulamentação para a amostragem, análise e apreciação da qualidade microbiológica de areias. O Programa Nacional de Avaliação Externa da Qualidade (PNAEQ), inserido no Departamento de Epidemiologia do Instituto Nacional de Saúde Dr. Ricardo Jorge, Portugal, implementou em 2015 um ensaio piloto no âmbito da avaliação externa da qualidade microbiológica de areias. Um dos principais objetivos é a harmonização da metodologia utilizada nos laboratórios, para avaliar a quantificação e identificação de microrganismos indicadores, quer bacterianos quer fúngicos, nas areias de praias, através da avaliação do desempenho dos resultados interlaboratoriais.
- Bacterial and fungal exposure in schools may influence asthma and allergy in childrenPublication . Cavaleiro Rufo, João; Madureira, J.; Paciência, I.; Aguiar, L.; Delgado, L.; Teixeira, J.P.; de Oliveira Fernandes, E.; Moreira, A.Development of allergic diseases may be regulated by microbial exposure. Children spend a lot of their time in schools, under an extensive diversity of biological agents, such as bacteria and fungi. This study aimed to characterize indoor air microbiological exposure in schools as a predictor of allergic sensitization and asthma in children.
- FRIESA (FRIo Extremo na SAúde) 2015/2016: relatório da fase-pilotoPublication . Silva, Susana Pereira; Antunes, Liliana; Marques, Jorge; Antunes, Sílvia; Dias, Carlos Matias; Nunes, BaltazarO inverno 2015/2016 revelou-se como muito quente em relação aos valores médios com os maiores desvios positivos a veri ficarem-se nas temperaturas mí nimas. Este facto foi redutor na an álise da previsão do Indice-FRIESA. No entanto, na totalidade da fase piloto do sistema FRIESA, de 01 de novembro a 31 de março, foram identi ficados dois períodos com índice-FRIESA, para a população com 65 e mais anos de idade, superior a zero mas inferior ao limite para passagem ao n ível de alerta, correspondendo a um "efeito pouco prov ável na mortalidade", tanto em Lisboa como no Porto. Estes períodos decorreram nos dias 20/01/2016 e entre 29/02/2016 e 02/03/2016 em Lisboa, e nos dias 02/12/2015 e entre 21 e 24/01/2016 no Porto.
- Hemorheological alterations in sickle cell anemia and their clinical consequences: the role of genetic modulatorsPublication . Silva, Marisa; Vargas, Sofia; Coelho, Andreia; Dias, Alexandra; Ferreira, Teresa; Morais, Anabela; Maia, Raquel; Kjollerstrom, Paula; Lavinha, João; Faustino, PaulaSickle cell anemia (SCA) is an autosomal recessive chronic hemolytic anemia, caused by homozygosity for the HBB:c.20A>T mutation. The disease presents with high clinical heterogeneity, stroke being the most devastating manifestation. This study aimed to identify genetic modulators of severe hemolysis and stroke risk in children with SCA, as well as understand their consequences at the hemorheological level. Sixty-six children with SCA were categorised according to their degree of cerebral vasculopathy (Stroke/Risk/Control). Relevant data were collected from patients’ medical records. Several polymorphic regions in genes related to vascular cell adhesion and tonus were characterized by molecular methodologies. Data analyses were performed using R software. Several in silico tools (e.g. TFBind, MatInspector) were applied to investigate the main variant consequences. Some genetic variants in vascular adhesion molecule-1 gene promoter and endothelial nitric oxide synthase gene were associated with higher levels of hemolysis and stroke events. They modify important transcription factor binding sites or disturb the corresponding protein structure/function. Our findings emphasize the relevance of the genetic variants in modulating the degree of hemolysis and development of cerebral vasculopathy due to their effect on gene expression, modification of protein biological activities related with erythrocyte/endothelial interactions and consequent hemorheological abnormalities in SCA.
- How important is the study of assay interference prior to nanotoxicity assessment? Case studyPublication . Bessa, Maria João; Reinosa, J.J.; Fernández, J.F.; Banãres, M.A.; Teixeira, J.P.; Costa, C.Most of the toxicity assays were developed for the evaluation of conventional drug compounds in vitro. In fact, researchers have realized that not all cytotoxic and genotoxic assays are appropriate for the evaluation of nanoparticle toxicity as several nanoparticles are capable to interfere with these methods. For instance, the binding and possible inactivation of assay components involved and/or the interference with colorimetric detection are examples of nanoparticle interference on the cytotoxic assays. For a correct assessment of the toxicity of the nanoparticles under evaluation, possible nanoparticle-assay interactions need to be identified. In the present work was evaluated the possible interferences between 3 nanomaterials (TiO2 nanoparticles, nanokaolin clay and TiO2 nanoparticles immobilized in nanokaolin substrates) and the cytotoxicity (MTT, neutral red uptake (NRU), alamar blue (AB) and LDH) and genotoxicity (alkaline comet assay) assays under evaluation.
- Analysis of cellular damage induced by silica-coated iron oxide nanoparticles on neuronal cellsPublication . Laffon, Blanca; Kiliç, G.; Fernandez Bertólez, N.; Costa, C.; Costa, S.; Teixeira, J.P.; Pásaro, E.; Valdiglesias, V.The objective of this work was to evaluate toxicity induced by silica-coated ION on a human neuronal cell line (SHSY5Y).
- Assessment of indoor environmental quality in elderly care centersPublication . Cano, M.; Nogueira, S.; Alves, M.; Papoila, A.L.; Aguiar, F.; Rosa, N.; Brás, M.C.; Quintas, M.C.; Pinhal, H.; Nogueira, Ana; Proença, C.; Teixeira, J.P.The aim of this study was to characterize indoor environmental quality in a representative sample of Elderly Care Centers (ECC) in order to associate it with ventilation, health and comfort of elderly people. Indoor air quality (IAQ) parameters and thermal comfort were measured twice, during winter and spring/summer seasons, from 18 Elderly Care Centers (ECC) located in Lisbon, with a total of 116 rooms evaluated.
- Functional genomics of Familial HypercholesterolemiaPublication . Alves, Ana CatarinaMain aim of the Portuguese Family Hypercholesterolemia study: to identify the cause of the dyslipidaemia in patients with a clinical phenotype of Familial Hypercholesterolaemia (FH).
- JA-CHRODIS Study Visit: Reykjavik, Iceland, 1st-2nd June 2016Publication . Joint Action CHRODISReport of JA-CHRODIS Study Visit - Iceland, under the Project CHRODIS - Work Package 5: Good practices in the field of health promotion and chronic disease prevention across the life cycle. The study visit in Iceland focused on the following two good practices: - The WELFARE WATCH, an intersectoral work aimed at vulnerable groups, transferred from National level (Iceland) to local level (the Sudurnes Region in Iceland) and international level (the Nordic Welfare Watch): - The NATIONAL CURRICULUM GUIDES ON HEALTH AND WELL-BEING as one of six fundamental pillars of education in Iceland, background and implementation.