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Cellular and molecular mechanisms of toxicity of ingested nanomaterials

2019-11-25Lecture Restricted access
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dc.contributor.authorGramacho, Ana Catarina
dc.contributor.authorRolo, Dora
dc.contributor.authorMartins, Carla
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorGonçalves, Lídia M.
dc.contributor.authorBettencourt, Ana
dc.contributor.authorAlvito, Paula
dc.contributor.authorPereira, Joana
dc.contributor.authorJordan, Peter
dc.contributor.authorSilva, Maria João
dc.contributor.authorLouro, Henriqueta
dc.date.accessioned2020-07-15T15:29:32Z
dc.date.available2020-07-15T15:29:32Z
dc.date.issued2019-11-25
dc.description.abstractThe technology based on manufactured nanomaterials (NMs) has been pointed as key enabling technology, due to its potential to improve many products and processes, namely in agriculture, food and feed industry. Many of such products, already available, have NMs such as titanium dioxide nanomaterials (TiO2) and the oral exposure may occur either directly, through the consumption of products/pharmaceuticals containing NMs, or indirectly, through the ingestion of foods contaminated with NMs released from food-contact materials or even through concentration in the food chain due to environmental accumulation. Therefore, the gastrointestinal tract (GIT) appears to be a probable route of exposure to NMs and may lead to systemic exposure if the body barriers are surpassed. One major concern for public health is that NMs may produce adverse outcomes (AO) such as genotoxic effects that are associated with increased risk of cancer. Although NMs have been extensively investigated in recent years, the studies have generated contradictory results, possibly due to differences in the physicochemical properties of the NMs studied and to other variables in the test systems. INSA has previously shown that NMs with the same chemistry, but differing in primary properties may yield different biological effects. Conversely, the NMs properties are context-dependent, i.e. can be affected by the surrounding matrix. These secondary features may be potentially more relevant for determining toxicological outcomes. In particular, processes like digestion may modify the NMs characteristics leading to unexpected toxicity in intestine cells. INGESTnano project aims to investigate the nano-bio interactions of NMs, at cellular and molecular level, in the context of intestinal tract and digestion processes, to better understand their potential negative impacts on human health with special reference to organ-specific cells. TiO2 has been selected as case-study to setup a workflow for addressing nanosafety concerns that may be in the future applied to other NMs to which GIT may be exposed. It is expected that this project will contribute to the safety evaluation of the TiO2 ingested, by elucidating key events (KE) elicited by these NMs and linking exposure to AO.pt_PT
dc.description.sponsorshipProject funded by FCT/MCTES through national funds (PTDC/SAU PUB/29481/2017), co-funded by UID/BIM/00009/2013 (Centre for Toxicogenomics and Human Health – ToxOmics, FCT), iMed.ULisboa (Pest-UID/DTP/04138/2018)pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7049
dc.language.isoengpt_PT
dc.subjectManufactured Nanomaterialspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectIngested Nanomaterialspt_PT
dc.subjectTitanium Dioxidept_PT
dc.subjectAdverse outcome pathwayspt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.subjectToxicologiapt_PT
dc.titleCellular and molecular mechanisms of toxicity of ingested nanomaterialspt_PT
dc.typelecture
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F00009%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FDTP%2F04138%2F2013/PT (2018)
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.titleWorkshop 'Nanotoxicology in the context of the safety assessment of nanomaterials', INSA, 25 novembro 2019pt_PT
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameRolo
person.familyNameJordan
person.familyNameSilva
person.familyNameLouro
person.givenNameDora
person.givenNamePeter
person.givenNameMaria Joao
person.givenNameHenriqueta
person.identifier157627
person.identifier.ciencia-idA01A-1F55-88DB
person.identifier.ciencia-id7710-643D-97A3
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.orcid0000-0003-2704-8648
person.identifier.orcid0000-0002-1425-9211
person.identifier.orcid0000-0002-6060-0716
person.identifier.orcid0000-0001-9744-7332
person.identifier.ridG-9335-2012
person.identifier.scopus-author-id28267819400
person.identifier.scopus-author-id55944437600
person.identifier.scopus-author-id6507971479
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typelecturept_PT
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