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Exposição precoce a micotoxinas: o contributo dos projetos MYCOMIX e earlyMYCO
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Advisor(s)
Abstract(s)
A exposição a contaminantes químicos nos primeiros 1000 dias de vida
tem sido associada a alterações de saúde, constituindo um domínio
emergente de pesquisa fundamental para o conhecimento do exposoma
humano. As micotoxinas produzidas por fungos integram a lista de contaminantes
químicos tóxicos presentes nos alimentos e têm efeitos carcinogénicos,
nefrotóxicos, hepatotóxicos e imunossupressores. A mucosa
intestinal é a primeira barreira biológica encontrada pelos alimentos contaminados
por micotoxinas após a ingestão, sendo pouco conhecidos os
potenciais efeitos decorrentes de uma exposição humana precoce a estes
contaminantes. Estudos recentes obtidos no âmbito do projeto MYCOMIX
evidenciaram que as crianças portuguesas até aos 3 anos estão expostas
a múltiplas micotoxinas através do consumo de alimentos à base de
cereais, o que constitui um risco potencial para a sua saúde. Este estudo
revelou a ocorrência de ocratoxina A, zearalenona e deoxinivalenol em,
respetivamente, 65%, 48% e 44% das amostras analisadas, confirmando
a exposição das crianças a várias micotoxinas através da alimentação.
Em virtude da toxicidade associada a estes contaminantes e à particular
vulnerabilidade deste grupo populacional, estes resultados abrem novas
perspetivas de investigação e reforçam a necessidade de avaliar a exposição
precoce das crianças a micotoxinas e o seu potencial impacto na
saúde, o que constitui o principal objetivo do projeto earlyMYCO.
Exposure to hazardous chemicals during the first 1000 days of life has been linked to an increased risk of a number of health disorders. Early-life exposure to chemicals is an emerging research field that needs to be explored to contribute to the understanding of human exposome. Mycotoxins are food chemical contaminants, well known for their carcinogenic, nephrotoxic, hepatotoxic and immunosuppressive effects. Intestinal mucosa is the first biological barrier encountered by ingested mycotoxins and potential consequences of an early-life exposure to these compounds is poorly documented. Recent studies obtained under the MYCOMIX project showed that Portuguese children up to 3 years old are exposed to multiple mycotoxins through consumption of cereal-based foods, which constitutes a potential health threat. This study revealed the occurrence of ochratoxin A, zearalenone and deoxynivalenol in, respectively, 65%, 48% and 44% of the analyzed samples, confirming children exposure to several mycotoxins through food. Given the toxicity of these compounds and that children are a particularly vulnerable group, there is an urgent need to assess the impact of early-life exposure to mycotoxins and their potential impact on human health, which is the main goal of earlyMYCO project.
Exposure to hazardous chemicals during the first 1000 days of life has been linked to an increased risk of a number of health disorders. Early-life exposure to chemicals is an emerging research field that needs to be explored to contribute to the understanding of human exposome. Mycotoxins are food chemical contaminants, well known for their carcinogenic, nephrotoxic, hepatotoxic and immunosuppressive effects. Intestinal mucosa is the first biological barrier encountered by ingested mycotoxins and potential consequences of an early-life exposure to these compounds is poorly documented. Recent studies obtained under the MYCOMIX project showed that Portuguese children up to 3 years old are exposed to multiple mycotoxins through consumption of cereal-based foods, which constitutes a potential health threat. This study revealed the occurrence of ochratoxin A, zearalenone and deoxynivalenol in, respectively, 65%, 48% and 44% of the analyzed samples, confirming children exposure to several mycotoxins through food. Given the toxicity of these compounds and that children are a particularly vulnerable group, there is an urgent need to assess the impact of early-life exposure to mycotoxins and their potential impact on human health, which is the main goal of earlyMYCO project.
Description
Artigo baseado no original publicado em:
Assunção R, Martins C, Vasco E, Jager A, Oliveira C, Cunha SC,
Fernandes JO, Nunes B, Loureiro S, Alvito P. Portuguese children dietary
exposure to multiple mycotoxins – An overview of risk assessment
under MYCOMIX project. Food Chem Toxicol. 2018;118:399-408.
https://doi.org/10.1016/j.fct.2018.05.040
Keywords
Micotoxinas Contaminantes Químicos Exposição Humana Exposição Precoce Alimentos à Base de Cereais Segurança Alimentar MYCOMIX earlyMYCO Saúde Pública Portugal
Pedagogical Context
Citation
Boletim Epidemiológico Observações. 2020 maio-agosto;9(27):16-27
Publisher
Instituto Nacional de Saúde Doutor Ricardo Jorge, IP