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Advisor(s)
Abstract(s)
During this reporting period, INSA pursued the cytotoxicity and genotoxicity studies in A549 cells, in order to contribute to the data comparison between exposure at the air liquid interface (ALI, performed by other partners) and under conventional submerged conditions. The genotoxicity and oxidative DNA damage of a dose-range of the TiO2 NM-1001a, following 3h exposure of A544 cells was assessed through the comet and the FPG-modified comet assay, respectively. Thereby, the studies with this NM are finished and data are being displayed in the ISA-TAB datasheets. In addition, the studies concerning the CeO2 nanomaterial (NM-02102) using the MTT and the plating efficiency assay (cytotoxicity assessment) and the comet assay plus the FPG-modified comet assay (genotoxicity assessment), were also concluded. Testing of the other two nanomaterials (TiO2 NM-100 and BaSO4 NM-220) planned for this task will start very soon in order to comply with the deadline for data presentation.
Description
Keywords
Genotoxicidade Ambiental Nanotoxicologia