| dc.contributor.author | Rocha, Raquel | |
| dc.contributor.author | Verdasca, Nuno | |
| dc.date.accessioned | 2019-04-08T10:02:23Z | |
| dc.date.available | 2019-04-08T10:02:23Z | |
| dc.date.issued | 2018-12 | |
| dc.description.abstract | Human Papillomavirus (HPV) is the etiological agent for cervical cancer and genital warts. Worldwide, cervical cancer is the fourth most common cancer in women and the high risk HPV (HR-HPV), namely HPV 16 and 18 are responsible for the most of the cases. The objective was to analyze the HR-HPV frequency in a group of women referred for HR-HPV testing. Clinical samples from 3117 women were perform by Cobas® HPV test (Roche Molecular Systems, CA, USA), this assay detected HPV 16 and HPV 18 and ‘Other HR-HPV’ (-31,-33,-35,-39,-45,-51,-52,-56,-58,-59,-66 and 68). Positive samples for ‘Other HR-HPV’ were sequenced for genotyping using MY09/11 primer´s. HR-HPV frequency was 20.8% (649/3117). Among the positive samples, ‘Other HR-HPV’ was the most common (72.8%; 473/649). HPV 16 and 18 were detected only in 22.8% (148/649) and 7.4% (48/649) of the cases, respectively. 7.4% (48/649) of the positive women were infected with more than one HPV (34 with ‘Other HR-HPV’ + HPV 16; 8 with ‘Other HR-HPV’ + HPV 18; 5 with ‘Other HR-HPV’ + HPV 16 + HPV 18 and 1 with HPV 16 + HPV 18). Sequencing of ‘Other HR-HPV’ is ongoing and preliminary results shown the majority frequency for HPV 31 (11.7%) followed by HPV 56 (9.1%) and 8.9% for the HPV 66. The HR-HPV frequency is high (20.8%), 30.4 % of these women were infected with HPV 16 or HPV 18 which is a high frequency. This study reveals the importance of the implementation of screening programs, and the use of HPV detection. | pt_PT |
| dc.description.version | N/A | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/6366 | |
| dc.language.iso | eng | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt_PT |
| dc.subject | Human Papillomavirus | pt_PT |
| dc.subject | High Risk Human Papillomavirus | pt_PT |
| dc.subject | Portuguese Women | pt_PT |
| dc.subject | Infecções Sexualmente Transmissíveis | pt_PT |
| dc.title | High Risk Human Papillomavirus in a Group of Portuguese Women | pt_PT |
| dc.type | other | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Lisboa, Portugal | pt_PT |
| oaire.citation.title | EUROGIN 2018 - International multidisciplinary HPV Congress, 2-5 dezembro 2018 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | other | pt_PT |
