DGH - Relatórios científicos e técnicos
URI permanente para esta coleção:
Navegar
Percorrer DGH - Relatórios científicos e técnicos por Objetivos de Desenvolvimento Sustentável (ODS) "03:Saúde de Qualidade"
A mostrar 1 - 3 de 3
Resultados por página
Opções de ordenação
- Deliverable D5.4 -1st closing data gaps report WP5 – Task 5.1. Partnership for the Assessment of Risks from ChemicalsPublication . Partnership for the Assessment of Risks from ChemicalsThis deliverable summarizes the preliminary results of the PARC WP5 Task 5.1, aiming to close key data gaps for substances of emerging concern. Focus is placed on two major substance groups: natural toxins and bisphenol A (BPA) alternatives, addressing both human and environmental health. For human health, prioritized mycotoxins (enniatins including beauvericin and Alternaria toxins) were tested across genotoxicity, endocrine disruption, developmental neurotoxicity, and immunotoxicity endpoints, employing both OECD test guidelines and new approach ethodologies (NAMs). In a parallel project, hazard testing of BPA alternatives examined metabolism, bioactivation, and toxicological profiles using as well OECD test guidelines and in vitro systems aligned with regulatory relevance. On the environmental side, aquatic organisms such as Daphnia magna, Lymnaea stagnalis, and Chlorella vulgaris were used to assess the ecotoxicity of selected natural toxins and BPA alternatives under standard OECD and ISO guidelines. Both single and mixture exposures were tested, revealing species- and compound specific effects and emphasizing the relevance of temperature and combined stressors in ecological risk assessment. Altogether, this first data gap report contributes to strengthening risk assessment capabilities across the EU by supporting better prioritization and regulation of under-studied substances. The data are being shared and discussed with regulatory agencies (EFSA, ECHA, EEA), and further testing is ongoing to complete hazard characterizations.
- Guiding principles for mixture threshold derivation from effect biomarkersPublication . OECD Environment Directorate Chemicals and Biotechnology Committee; OECD Environment Health and Safety Division__APAGARForeword: Currently available assessment approaches for cumulative risk of chemical mixtures can only be applicable to a small number of substances present at workplaces and in the environment. We cannot anticipate a significant change of this situation in the near future due to extensive data need for cumulative risk assessments. Presently, effect biomarkers are the most direct option to address the risk of known and unknown mixtures in an integrative way. Traditional occupational health risk assessments often rely on external exposure measurements, such as air monitoring, which may not fully capture the complexities of workplace exposures. Human biomonitoring is used to measure internal exposures or effects in exposed individuals or groups from all potential routes of exposure (i.e., inhalation, oral, and dermal). Exposure to mixtures in the workplace and environment is the most common chemical exposure scenario in our daily lives. However, methods for assessing the risks and for setting mixture threshold limits to avoid adverse effects lack global harmonization. Monitoring of effect biomarkers can support regulatory risk assessment in multiple ways. An effect biomarker indicates a stressor-induced biological effect which can be associated with a disease and can be interpreted as a potential predictor of a downstream effect i.e. measuring a key event in a Mode of Action (MoA) or Adverse Outcome Pathway (AOP). Thus, biomarkers can provide an integrated measure of the response to relevant stressors by all routes of known and unknown exposures. However, effect biomarker responses are usually not straightforward to interpret regarding their predictive value to indicate adverse effects. A systematic understanding of the relevance of effect biomarker data will enhance the protection of workers and/or ecosystems, if used under appropriate ethical and regulatory frameworks. Therefore, harmonized guidance for assessing effect biomarkers and their application to risk assessments are needed. The guiding principles proposed in this document describe the key concepts for the derivation and interpretation of mixture thresholds* for selected effect biomarkers for use in occupational or ecological risk assessments. The aim of these guiding principles is to present a harmonized assessment approach which will save resources and promote consistency across regulatory agencies at national and international levels. The development of this document was a joint activity of the Organisation for Economic Co-operation and Development (OECD) Working Party on Exposure Assessment & Working Party on Hazard Assessment (WPEA & WPHA) in collaboration with more than 90 experts from 25 countries and other stakeholders (see chapter 8 project participation). The activity was started in October 2022 and the development of this guiding principles document was co-led by Robert Pasanen-Kase (SECO*, CH) as coordinator, Maryam Zare-Jeddi (BIAC*), Nancy B. Hopf (Unisanté, CH), Susana Viegas (ENSP*/UNL, PT), Dan Villeneuve (US-EPA*, US), Martin Wilks and Rex FitzGerald (University of Basel, CH), Radu Corneliu Duca (LNS*, LU) and the OECD Secretariat. The document was drafted in close collaboration with experts providing input on different aspects of human and environmental effect-biomonitoring including Bernice Scholten, (TNO* , NL), Eszter Simon (FOEN* , CH), Devika Poddalgoda (Health Canada, CAN), Anna Bal Price (JRC*, EU); Vicente Mustieles, Antonio Hernandez-Jerez (University of Granada, ES), Christoph van Thriel (IFADO* , DE), Stefano Bonassi (IRCCS*, San Raffaele Roma, IT), Michael Fenech (University of South Australia, AUS), Sophie Ndaw (INRS*, FR), Christina Pieper (German Federal Institute for Risk Assessment, DE), Lucian Farcal, Alicia Paini (EFSA*, EU). The initial draft guidance document was reviewed in 2025 by expert group (see chapter 8) and WPEA & WPHA members and was commented by eleven experts from six different organisations / institutes / companies and was finalized. This adopted biomonitoring guiding principles document is published under the responsibility of the Chemical and Biotechnology Committee of the OECD.
- Relatório Saúde e Ambiente 2024Publication . Observatório Português da Saúde e Ambiente; Nicola, Paulo Jorge; Campos, LuísO Observatório Português da Saúde e Ambiente foi criado pelo Conselho Português para a Saúde e Ambiente (CPSA) em 2024 e tem como objetivo avaliar e monitorizar a relação entre as alterações climáticas, a degradação ambiental e a saúde humana em Portugal. O relatório publicado, trata-se de uma publicação composta por capítulos temáticos, da autoria de equipas especializadas. Áreas em destaque: 1. Determinantes Ambientais da Saúde, nomeadamente a sobrepopulação, as alterações climáticas, a poluição e degradação dos ecossistemas, e a biodiversidade e recursos naturais; 2. Impacto na Saúde Humana, das doenças associadas a fatores ambientais, zoonoses e doenças transmitidas por vetores, poluição química e saúde mental; 3. Ações de Mitigação e Adaptação, ao nível dos compromissos e desafios, mas também das iniciativas municipais; 4. Impacto Ambiental do Setor da Saúde, a sua pegada ambiental, bem como as iniciativas e áreas negligenciadas; 5. Resiliência do Sistema de Saúde, os seus desafios estruturais e ao nível dos recursos humanos; 6. Literacia, Educação e Investigação, desde a consciencialização, à formação e à investigação; 7. Boas Práticas e Recomendações.