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Orientador(es)
Resumo(s)
This deliverable summarizes the preliminary results of the PARC WP5 Task 5.1, aiming to close key data gaps for substances of emerging concern. Focus is placed on two major substance groups: natural toxins and bisphenol A (BPA) alternatives, addressing both human and environmental health. For human health, prioritized mycotoxins (enniatins including beauvericin and Alternaria toxins) were tested across genotoxicity, endocrine disruption, developmental neurotoxicity, and immunotoxicity endpoints, employing both OECD test guidelines and new approach ethodologies (NAMs). In a parallel project, hazard testing of BPA alternatives examined metabolism, bioactivation, and toxicological profiles using as well OECD test guidelines and in vitro systems aligned with regulatory relevance. On the environmental side, aquatic organisms such as Daphnia magna, Lymnaea stagnalis, and Chlorella vulgaris were used to assess the ecotoxicity of selected natural toxins and BPA alternatives under standard OECD and ISO guidelines. Both single and mixture exposures were tested, revealing species- and compound specific effects and emphasizing the relevance of temperature and combined stressors in ecological risk assessment.
Altogether, this first data gap report contributes to strengthening risk assessment capabilities across the EU by supporting better prioritization and regulation of under-studied substances. The data are being shared and discussed with regulatory agencies (EFSA, ECHA, EEA), and further testing is ongoing to complete hazard characterizations.
Descrição
Work package WP5 – Hazard Assessment. Task T5.1 – Toxicity testing addressing data gaps of concern: Responsible author(s) Holden , Kiara Aiello; Behr, Anne-Cathrin; Marko , Doris; Asselman, Jana; Kyriakopoulou, Katerina; Co-authors: Dirven, Hubert; Snapkow, Igor; Silva, Maria João (INSA); Louro, Henriqueta (INSA); Tait, Sabrina; Testai, Emanuela; Buratti, Franca Maria; Viguie , Catherine; Zalko, Daniel; Mahouty-Kodja, Sakina; Corsini, Emanuela; Puts, Regina.
Palavras-chave
Natural Toxins BPA Alternatives Genotoxicity Endocrine Disruptive Effects Immunotoxicity Developmental Neurotoxicity (DNT) Ecotoxicology In Vitro Risk Assessment New Approach Methodologies (NAMs) Genotoxicidade Ambiental