Browsing by Issue Date, starting with "2018-05-21"
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- Aula 1: Toxicologia GenéticaPublication . Silva, Maria João; Louro, Henriqueta1. Introdução à Toxicologia Genética. Objectivos gerais 2. Interação de fatores ambientais com o genoma humano – efeitos na saúde 3. Da genotoxicidade à carcinogénese 4. Mecanismos moleculares de mutagénese 4.1. Relação entre lesão do DNA, reparação, mutação e cancro
- Children exposure assessment to food additives: an exploratory studyPublication . Calmeiro, Ana; Alvito, Paula; Vasco, ElsaThe increase of processed products in children´s diet has been followed by an increase in the consumption of food additives. The present exploratory study aimed to: i) evaluate the exposure of a Portuguese group of children, from 0 to 3 years of age, to food additives; ii) study its association with age, gender and Body Mass Index (BMI); iii) identify the main food categories that contribute to food additives intake.
- Aula 2: Toxicologia GenéticaPublication . Silva, Maria João; Louro, Henriqueta5. Avaliação do efeito cancerígenos de agentes químicos e físicos 5.1. Ensaios de longo-termo em roedores 6.2. Avaliação de curto-termo para avaliação de efeitos genotóxicos in vitro e in vivo 6.3. Linhas orientadoras para produtos farmacêuticos (ICH guidelines)
- Risk assessment of foods consumed by children: a case studyPublication . Assunção, Ricardo; Martins, Carla; Vasco, Elsa; Nunes, Baltazar; Alvito, PaulaChildren can be biologically more sensitive to certain toxicants on a body weight basis than adults. Current understanding of the rates of maturation of metabolism and evidence from case studies indicated that this population group typically lack the capacity to detoxify and eliminate substances as readily as adults. Consequently, a disproportionate burden of exposure from food contaminants, as mycotoxins, is borne by children. In many parts of the world, children are routinely exposed to many mycotoxins via food chain and aflatoxins, fumonisins and deoxynivalenol are the three most common. Risk assessment constitutes an essential component in modern science-based food safety systems and plays a growing and important role in guiding food safety authorities. Most studies have focused on the risk assessment of single mycotoxins and there are scarce data concerning the risk associated with human exposure to multiple mycotoxins in foods, especially for those intended for children consumption. MYCOMIX, a recent Portuguese project (https://www.youtube.com/watch?v=CsKaz3mt2J4), assessed for the first time, the risk associated with the simultaneous exposure to 13 mycotoxins in cereal-based food products usually consumed by children until 3 years old from Lisbon region, Portugal. Results on mycotoxins occurrence showed that 94% of the analysed samples were contaminated with at least one mycotoxin, although at levels below the legislated limits. Co-contamination was observed in 75% of the analysed samples. Estimated aflatoxins exposure suggested a potential adverse health effect for percentiles of intake above or equal to P50, determined through margin of exposure concept. Considering the potential benefit effects linked to the consumption of cereal-based products, as those associated with fibres, future studies considering the risk-benefit assessment are of utmost importance to establish recommendations based on scientific evidences to protect children’s health.