Browsing by Issue Date, starting with "2015-10-16"
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- ValCAP – Valorização da Casca de Arroz Português: Resultados FinaisPublication . Delgado, Inês; André, Catarina; Coelho, Inês; Motta, Carla; Nascimento, Ana; Castanheira, IsabelNo projeto ValCAP, o INSA tem a responsabilidade de caracterizar o perfil químico da casca de arroz nos componentes com relevância para a saúde.
- Bioaccessibility assessment of patulin and ochratoxin A in cereal and fruit based baby foods using a harmonized in vitro digestion model: contribution for the risk assessment of chemical mixturesPublication . Assunção, Ricardo; Martins, Carla; Duarte, Lecrerc; Alvito, PaulaPeople, animals and the environment can be exposed to multiple chemicals at once from a variety of sources, but current risk assessment is usually carried out on one chemical substance at a time. Mycotoxins are fungal natural contaminants commonly found in a variety of foods including baby foods and have been found in cereal and fruit based baby foods. In human health risk assessment, ingestion of food is considered a major route of exposure to many contaminants including mycotoxins, although the total amount of an ingested contaminant (external dose) does not always reflect the amount that is available to the body (internal dose). (...)
- Maternal age and congenital anomalies: 11 years of the national registry of congenital anomaliesPublication . Braz, Paula; Machado, Ausenda; Dias, Carlos MatiasBackground: Congenital anomalies (CA) can be defined as structural or functional anomalies that occur during pregnancy and can be identified prenatally, at birth or later in life. In Portugal, since 1997 the Nacional Registry of Congenital Anomalies (RENAC), a population-based registry, is a strategic instrument in surveillance and improve knowledge in this field. The aim of this study is to investigate for the period 2000-2010, the relationship between maternal age, young or advanced and the risk of structural congenital anomalies.
- How mRNA translation is involved in modulating nonsense-mediated decay in transcripts with short open reading framesPublication . Onofre, Cláudia; Menezes, Juliane; Peixeiro, Isabel; Costa, Nuno; Barbosa, Cristina; Romão, LuísaNonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and selectively degrades mRNAs carrying premature termination codons (PTCs). In addition, several studies have also implicated NMD in the regulation of steady-state levels of physiological mRNAs, and examples of natural NMD targets are transcripts containing upstream short open reading frames or long 3’ untranslated regions. The strength of the NMD response appears to reflect multiple determinants on a target mRNA. We have reported that human mRNAs with a PTC in close proximity to the translation initiation codon (AUG-proximal PTC), and thus, with a short open reading frame, can substantially escape NMD. Our data support a model in which cytoplasmic poly(A)-binding protein 1 (PABPC1) is brought into close proximity with an AUG-proximal PTC via interactions with the translation initiation complexes. This proximity of PABPC1 to the AUG-proximal PTC allows PABPC1 to interact with eRF3 with a consequent enhancement of the release reaction and repression of the NMD response. Here, we provide strong evidence that the eIF3 is involved in delivering eIF4G-associated PABPC1 into the vicinity of the AUG-proximal PTC. In addition, we dissect the biochemical interactions of the eIF3 subunits in bridging PABPC1/eIF4G complex to the 40S ribosomal subunit. Together, our data provide a framework for understanding the mechanistic details of PTC definition and translation initiation.
- Molecular diagnosis of Familial Hypercholesterolemia and functional studies of missense variants in the LDLR genePublication . Valentim de Azevedo, Sílvia