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Browsing by Issue Date, starting with "2012-01-10"

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  • Toxinfecções alimentares Investigação epidemiológica laboratorial - dados do INSA
    Publication . Correia, Cristina Belo
    Infecções e intoxicações alimentares. Reporte dos dados do INSA, I.P. à Autoridade Europeia de Segurança Alimentar.
    2012-01-10Lecture Restricted access Show more
  • Evidence for epistatic gene interactions between growth factor genes in stroke outcome
    Publication . Manso, H.; Krug, T.; Sobral, J.; Albergaria, I.; Gaspar, G.; Ferro, J.M.; Oliveira, S.A.; Vicente, A.M.
    Background and purpose:  Growth factors are thought to modulate neurological function in stroke recovery through effects in angiogenesis, neurogenesis, and neuroprotection. Methods:  We tested the association of variants in the brain-derived neurotrophic factor (BDNF), fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor A (VEGFA) genes, and epistatic interactions between them, with functional outcome in a sample of 546 stroke patients. Results:  While none of the tested genes was independently associated with stroke outcome, two significant gene-gene interaction models were identified. One model combined one BDNF and three FGF2 markers, with a global odds ratio (OR) (95% confidence interval [CI]) of 4.15 [2.86-6.04]. The second model included one FGF2 and two VEGFA markers with a global OR [95% CI] = 2.54 [1.76-3.67]. Conclusions:  The results provide evidence for gene interactions in stroke outcome, highlighting the complexity of the recovery mechanisms after a stroke event.
    2012-01-10Journal article Restricted access Show more