Evidence for epistatic gene interactions between growth factor genes in stroke outcome

Manso, H.; Krug, T.; Sobral, J.; Albergaria, I.; Gaspar, G.; Ferro, J.M.; Oliveira, S.A.; Vicente, A.M.

http://hdl.handle.net/10400.18/870

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Abstract(s)

Background and purpose: Growth factors are thought to modulate neurological function in stroke recovery through effects in angiogenesis, neurogenesis, and neuroprotection. Methods: We tested the association of variants in the brain-derived neurotrophic factor (BDNF), fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor A (VEGFA) genes, and epistatic interactions between them, with functional outcome in a sample of 546 stroke patients. Results: While none of the tested genes was independently associated with stroke outcome, two significant gene-gene interaction models were identified. One model combined one BDNF and three FGF2 markers, with a global odds ratio (OR) (95% confidence interval [CI]) of 4.15 [2.86-6.04]. The second model included one FGF2 and two VEGFA markers with a global OR [95% CI] = 2.54 [1.76-3.67]. Conclusions: The results provide evidence for gene interactions in stroke outcome, highlighting the complexity of the recovery mechanisms after a stroke event.

Keywords

Epidemiology Genetic Association Study Stroke Doenças Cardio e Cérebro-vasculares

URI

http://hdl.handle.net/10400.18/870

Citation

Eur J Neurol. 2012 Jan 10. doi: 10.1111/j.1468-1331.2011.03625.x. [Epub ahead of print]

Publisher

Wiley-Blackwell

Collections

DPSPDNT - Artigos em revistas internacionais

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