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Evidence for epistatic gene interactions between growth factor genes in stroke outcome

2012-01-10Journal article Restricted access
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dc.contributor.authorManso, H.
dc.contributor.authorKrug, T.
dc.contributor.authorSobral, J.
dc.contributor.authorAlbergaria, I.
dc.contributor.authorGaspar, G.
dc.contributor.authorFerro, J.M.
dc.contributor.authorOliveira, S.A.
dc.contributor.authorVicente, A.M.
dc.date.accessioned2012-05-31T14:42:25Z
dc.date.available2012-05-31T14:42:25Z
dc.date.issued2012-01-10
dc.description.abstractBackground and purpose:  Growth factors are thought to modulate neurological function in stroke recovery through effects in angiogenesis, neurogenesis, and neuroprotection. Methods:  We tested the association of variants in the brain-derived neurotrophic factor (BDNF), fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor A (VEGFA) genes, and epistatic interactions between them, with functional outcome in a sample of 546 stroke patients. Results:  While none of the tested genes was independently associated with stroke outcome, two significant gene-gene interaction models were identified. One model combined one BDNF and three FGF2 markers, with a global odds ratio (OR) (95% confidence interval [CI]) of 4.15 [2.86-6.04]. The second model included one FGF2 and two VEGFA markers with a global OR [95% CI] = 2.54 [1.76-3.67]. Conclusions:  The results provide evidence for gene interactions in stroke outcome, highlighting the complexity of the recovery mechanisms after a stroke event.por
dc.identifier.citationEur J Neurol. 2012 Jan 10. doi: 10.1111/j.1468-1331.2011.03625.x. [Epub ahead of print]por
dc.identifier.issnESSN: 1468-1331
dc.identifier.otherdoi:10.1111/j.1468-1331.2011.03625.x
dc.identifier.urihttp://hdl.handle.net/10400.18/870
dc.language.isoengpor
dc.publisherWiley-Blackwellpor
dc.subjectEpidemiologypor
dc.subjectGenetic Association Studypor
dc.subjectStrokepor
dc.subjectDoenças Cardio e Cérebro-vascularespor
dc.titleEvidence for epistatic gene interactions between growth factor genes in stroke outcomepor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleEuropean Journal of Neurologypor
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

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