Browsing by Author "Serrenho, I."
Now showing 1 - 3 of 3
Results Per Page
Sort Options
- 4th International Conference on Food Contaminants (ICFC) 2021: Challenges on early-life exposure: Book of abstractsPublication . Vasco, E.; Martins, C.; Serrenho, I.; Assunção, R.; Alvito, P.(...) Exposure to hazardous chemicals during first 1000 days of life has been linked to an increased risk of a number of health disorders.There is growing evidence that early-life exposure to chemical hazards can lead to non-communicable diseases (NCDs) in adulthood including cancer, diabetes, obesity and auto-immune diseases. Because cells are rapidly dividing and organ systems are developing during childhood and adolescence, exposure to carcinogens during these early life stages is a major risk factor for cancer later in life. Exposure during early-life due to food ingestion of toxic chemicals seems to have a critical role on the rapid epidemiological rise of obesity as well as a trans-generational transmission of risk of later obesity. Some reports provide evidence of a link between early-life adverse events (ELAE)-induced intestinal barrier disruption, inflammation, epigenetic modifications, and the occurrence of late metabolic disorders (MD), including obesity and type 2 diabetes (T2D). Changes in neurobehavior, sexual development, the prevalence of asthma and allergy, among others, have shown to be associated with chemical contaminants exposure at early-life stages. Early-life is a critical sensitive window of susceptibility. Therefore, this conference will aim to gather research scientists, health and food professionals, regulatory entities, and students to discuss different perspectives on this particular period of life in order to debate i) the risks associated with exposing vulnerable populations to chemicals, in particular, food contaminants and ii) toxic effects of early-life exposure to chemicals. This conference is promoted within the framework of the earlyMYCO national project, funded by the Foundation for Science and Technology (FCT), Portugal, aiming to assess the impact of early-life exposure to mycotoxins and their potential impact on human health. (...)
- Effect of Aflatoxin B1 in both Caco-2 and Caco-2/HT29-MTX modelsPublication . Serrenho, I.; Vidal, N.; Rolo, D.; Louro, H.; Pereira, J.; Matos, P.; Jordan, P.; Alvito, P.About effect of Aflatoxin B1 in both Caco-2 and Caco-2/HT29-MTX models within the scope of the intestinal absorption assessment and enabling formulations.
- Exposure of gastrointestinal tract to aflatoxin B1: an overlooked impact?Publication . Serrenho, I.; Assunção, R.; Alvito, P.Introduction: Human exposure to aflatoxin B1 (AFB1) through contaminated food ingestion and its impact on the gastrointestinal tract (GIT) is a field of scientific growing interest. Beyond the recognized carcinogenic potential, AFB1 has the ability to disrupt the intestinal barrier affecting its balance and dynamics, and could promote the development of chronic intestinal inflammation, among other pathologies. These conditions may affect the general population and could constitute a matter of increased concern for vulnerable populations, such as pregnant women and children, especially when AFB1 transfer through the placenta is considered. Since it is expected to occur an increase of AFB1 exposure through food due to climatic change and this could consequently contribute to an increase in number of GIT pathologies, this study aims to raise awareness of health professionals for the potential impact of AFB1 in the GIT and associated health effects. Methodology: The bibliographic search was carried out in 2021, using the Web of Science and PubMed search engines, including specific key words, for the period 2000-2020. From a total of 265 references found, 208 were excluded (duplicates and studies outside the intended context) and 57 were analyzed. Results and Conclusion: The significant impact of AFB1 in the intestinal barrier was evidenced, compromising the intestinal immunity and, consequently, affecting the health of the considered organism. As it becomes increasingly evident that early exposure to chemical contaminants can lead to the onset of diseases in adults such as infections, cancer, diabetes and autoimmune diseases, it is therefore important to develop studies aiming to assess the importance of the environment intrauterine and first years of life in the health of the child and the future adult. The raise of awareness of health professionals of a possible increase in number of GIT pathologies associated to exposure to AFB1 arising from climatic change is therefore crucial to empower health professionals to act based on a deeper scientific knowledge.