Browsing by Author "Gouveia, Bruna"
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- Exposição a arsénio em Portugal continental: resultados preliminares do estudo INSEF-ExpoQuimPublication . Namorado, Sónia; Delgado, Inês; Coelho. Inês; Gueifão, Sandra; Ventura, Marta; Alves, Clara Alves; Castilho, Emília; Cordeiro, Eugénio; Dinis, Ana; Gouveia, Bruna; Prokopenko, Tamara; Vargas, Patrícia; Silva, SusanaO arsénio é um elemento naturalmente presente no meio ambiente e que também pode ser libertado em resultado de atividades antropogénicas, podendo encontrar-se na forma de compostos orgânicos ou inorgânicos. O arsénio é considerado pela Organização Mundial de Saúde como um dos dez químicos de maior preocupação para a saúde pública, uma vez que o arsénio e os compostos inorgânicos de arsénio estão classificados como cancerígenos pela Agência Internacional para a Investigação do Cancro. A exposição a arsénio inorgânico ocorre principalmente por via alimentar, através do consumo de água e de alimentos contaminados. Em Portugal são escassos os dados sobre a exposição a arsénio na população geral, pelo que o objetivo do presente estudo é a caracterização da exposição da população adulta portuguesa a arsénio, utilizando amostras de urina colhidas num estudo populacional nacional ( INSEF-ExpoQuim). O presente trabalho incluiu 171 participantes no estudo INSEF-ExpoQuim que forneceram uma amostra de urina para análise da concentração de arsénio total por espectrometria de massa com plasma indutivo acoplado ( ICP-MS ). Observou-se uma média geométrica de 47,1 μg As/L [ IC95%: 41,4-53,5 ] e 8,8% dos indivíduos apresentavam valores de arsénio considerados elevados. Não se observaram diferenças nos níveis de arsénio por sexo, grupo etário, grau de urbanização da área de residência, nível de escolaridade e situação face ao trabalho. Os resultados preliminares obtidos apontam para a necessidade de monitorização dos níveis de arsénio na população portuguesa.
- Exposure of the Portuguese adult population to arsenic: preliminary results of a human biomonitoring studyPublication . Namorado, Sónia; Coelho, Inês; Ventura, Marta; Gueifão, Sandra; Rego, Andreia; Castanheira, Isabel; Alves Alves, Clara; Castilho, Emília; Cordeiro, Eugénio; Dinis, Ana; Gouveia, Bruna; Prokopenko, Tamara; Vargas, Patrícia; Silva, Susana; Gaio, Vânia; Nunes, Baltazar; Matias Dias, CarlosBACKGROUND AND AIM:Although arsenic is an element naturally present in the environment, it is highly toxic in its inorganic forms. Exposure can occur through consumption of drinking water and contaminated food. Long-term exposure was shown to be associated with negative health outcomes. Nevertheless, data on the Portuguese population’s exposure to arsenic is scarce. As such, the aim of this work was to assess the exposure to Arsenic in the Portuguese population using samples collected in the study "Exposure of the Portuguese Population to Environmental Chemicals: a study nested in INSEF 2015" (INSEF-ExpoQuim), developed as an aligned study of the European Human Biomonitoring Initiative (HBM4EU). METHODS: INSEF-ExpoQuim was an epidemiologic study nested in INSEF 2015 including 270 participants aged 28-39 years,living in Portugal for more than 12 months and able to follow an interview in Portuguese. Fieldwork was developed between June 2019 and February 2020. First morning urine samples were collected along with data on socio-demographic characteristics, living conditions and residential history, habits/lifestyle, nutrition, health, occupation and substance specific information covering nearly all exposure pathways. Procedures followed the guidelines of the HBM4EU project. Total urinary arsenic is currently being determined by inductively coupled plasma mass spectrometry. RESULTS:Preliminary results for 38 samples yielded total urinary arsenic concentrations ranging from 11 to 462 μg/L with an average of 86 ± 94 μg/L. After completion of the determination of the urinary arsenic levels for all the samples a complete analysis of the data will be performed. CONCLUSIONS:Results from this study will contribute to the knowledge on the Portuguese population’s exposure to arsenic and may support the development and implementation of policy measures aimed at minimizing exposure to this chemical and improving the health of the population.
- INSEF-ExpoQuim: assessing the exposure of the Portuguese population to chemicalsPublication . Namorado, Sónia; Kislaya, Irina; Alves-Alves, Clara; Castilho, Emília; Cordeiro, Eugénio; Dinis, Ana; Gouveia, Bruna; Prokopenko, Tamara; Vargas, Patrícia; Nunes, Baltazar; Matias Dias, CarlosIntroduction: Exposure to hazardous chemicals may endanger human health and pollute the environment. To assess and minimize the risks associated with the use of chemicals it is essential to know whether and to what extent these substances are present in the human body. We report preliminary results of the recruitment phase in the study of Exposure of the Portuguese Population to Environmental Chemicals: a study nested in INSEF 2015 (INSEF-ExpoQuim). Methods: INSEF-ExpoQuim is an epidemiologic study nested in INSEF 2015 targeting 300 non-institutionalized individuals aged 28-39 years, living in Portugal for more than 12 months, able to follow an interview in Portuguese. Fieldwork started in June 2019 and is ongoing. Procedures are according to the guidelines of the HBM4EU project. Selected individuals receive an invitation letter and are later contacted by phone to schedule sample collection and the telephone interview. Urine samples for determination of heavy metals, bisphenols and Polycyclic Aromatic Hydrocarbons are collected, as well as data on socio-demographic characteristics, living conditions and residential history, habits/lifestyle, nutrition, health, occupation and substance specific information covering nearly all exposure pathways. Results: Up to date 384 of the 848 eligible individuals were successfully contacted (45,3%), of which 172 accepted to participate in INSEF-ExpoQuim corresponding to a participation rate of 20%. Conclusions: Results from INSEF-ExpoQuim will contribute to reduce the health impact that could result from the exposure of the population residing in Portugal to environmental chemicals, by producing high quality data on the actual exposure of the Portuguese population to hazardous chemicals, in order to support the development and implementation of policy measures aimed at minimizing exposure to those chemicals.
- Use of Human Biomonitoring in food risk assessment: assessing exposure to bisphenols in PortugalPublication . Namorado, Sónia; Kislaya, Irina; Alves-Alves, Clara; Castilho, Emília; Cordeiro, Eugénio; Dinis, Ana; Gouveia, Bruna; Prokopenko, Tamara; Vargas, Patrícia; Nunes, Baltazar; Matias Dias, CarlosBisphenols are among the chemicals with the highest production volume worldwide and are used to make polycarbonate plastic containers for food use, such as beverage containers and plastic dinnerware, and in the internal coatings of food and beverage cans among other products. According to the scientific literature, small amounts of these compounds migrate from packaging into food resulting in human exposure. Although numerous studies have been carried out in order to assess its effects on human health, there are still uncertainties concerning the possible toxic effects of these compounds. Nevertheless, the most commonly used bisphenol, bisphenol A (BPA), is considered an endocrine disrupting compound. As a consequence, current European legislation prohibits the use of BPA in baby bottles, infant sipping cups and in the coating of food containers for children up to 3 years old and significantly tightens the restrictions on the use of BPA in other food contact materials. This has led to the replacement of BPA by other bisphenols, such as BPS and BPF, whose health effects are still largely unknown. Considering the above and that there is no data on the exposure of the Portuguese population to these compounds, a new project named INSEF-ExpoQuim is currently being developed by the National Health Institute Doutor Ricardo Jorge, in cooperation with the five Regional Health Administrations and the Regional Health Secretariats of the Autonomous Regions of the Azores and Madeira, as part of the European Human Biomonitoring Initiative HBM4EU with the aim to assess exposure to bisphenols in the Portuguese population and contribute to the food risk assessment of bisphenols in Portugal. It is expect that project results will contribute to the reduction of the impact on the health of the Portuguese population that could result from the exposure to these chemicals, by producing high quality data on the actual exposure of the population, in order to support the development and implementation of policy measures aimed at minimizing exposure.