Percorrer por autor "Fernandes, Ruben"
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- Commentary: Theileria Parasites Secrete a Prolyl Isomerase to Maintain Host Leukocyte TransformationPublication . Fernandes, Ruben; Ferreira, Stephanie; Botelho, Mónica C.The genus Theileria comprises apicomplexan parasites that are tick-transmitted and infect ruminants with important trade and industry impact in endemic countries. Infectious agents build up elaborate machinery to work together by means of host cell pathways and takeover their genetic and epigenetic mechanisms to modify phenotypic status of host cells. Among the Apicomplexa phylum encompassing obligate intracellular parasites, the only genus that introduces its DNA into mammalian host cells is Theileria, which is known to cause veterinary and human diseases. Various species, including Theileria parva and Theileria annulata, infect leukocytes causing alterations in their phenotypes that are common with several cancers, remarkably immortalization, hyperproliferation, and spreading. (...)
- Fasciola Hepatica Extract Induces Cell Death of Mammalian CellsPublication . Ferreira, Stephanie; Fernandes, Ruben; Botelho, Monica CBackground: Fascioliasis is a neglected tropical disease that affects poor people from poor and developing countries. In the world, it has been estimated that at least 2.6 million people are affected with this disease. The International agency for Research on Cancer, states that O. viverrini and C. sinensis, also liver flukes, are considered as definitive causes of cholangiocarcinoma. However, fascioliasis caused by F. hepatica has not been associated with cancer to date. There are not any known causative associations between this parasite and liver cancer (cholangiocarcinoma). Methods: Chine Hamster Ovary (CHO) cells were treated with F. haepatica extracts and cell proliferation was assessed by using the indirect method for estimating cell number based on the mitochondrial activity with MTS cell proliferation reagent. We observed unexpected death of these cells when treated with F. haepatica extracts. Results and Conclusion: We now hypothesize that this parasite could be used as a medically-important trematode pathogen in cancer therapy.
- Pathways of estrogen metabolism underlying the association between Schistosoma haematobium and bladder cancerPublication . Gonçalves, Ana Rita; Luis, Carla; Soares, Raquel; Fernandes, Ruben; Botelho, Monica C.Communication on pathways of estrogen metabolism underlying the association between Schistosoma haematobium and bladder cancer.
- Schistosomiasis and infertility: what do we know?Publication . Ribeiro, Ana Rita; Luis, Carla; Fernandes, Ruben; Botelho, Monica C.There is increasing attention on the complex interactions occurring between schistosome parasites and their hosts. However, little is known about the occurrence, epidemiology, and mechanisms of schistosomiasis-associated infertility. In this article, we argue that an in-depth understanding of the interplay between parasites and the host endocrine system may significantly enhance current knowledge of infertility in infected individuals. We discuss the basic hormonal mechanisms that may lead to the discovery of entirely novel anthelmintic interventions against schistosomiasis.
- The cancer hygiene hypothesis: from theory to therapeutic helminthsPublication . Fernandes, Ruben; Alves, Helena; Botelho, Monica C.The “Hygiene Hypothesis” was postulated by David Strachan in 1989 to explain for the rapid 20th century increase in allergic diseases such as asthma. In this hypothesis, children from developed countries living in ultra-hygienic environments and avoiding exposure to viruses, bacteria, and parasites, especially helminthes, have an increased risk of atopic disorders.