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Percorrer por autor "Dias, A."

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  • Intra-hospital mortality for community-acquired pneumonia in mainland Portugal between 2000 and 2009
    Publication . Teixeira-Lopes, F.; Cysneiros, A.; Dias, A.; Durão, V.; Costa, C.; Paula, F.; Serrado, M.; Nunes, Baltazar; Diniz, A.; Froes, F.
    Introduction: Community-acquired pneumonia (CAP) remains a common and serious infection with wide variability in intra-hospital mortality. Methods: We performed a retrospective analysis of adult patients admitted with CAP in mainland Portugal between the years 2000 and 2009. Results: The intra-hospital mortality rate was 20.4% with deaths in all age groups. The average age of deceased patients was 79.8 years, significantly higher than surviving patients with 71.3 years. Patients aged 50 or more presented a relative risk of death 4.4 times the risk of patients under this age group. Likewise, in patients aged 65 or more the risk of death was 3.2 times the risk of patients <65 years. Men died more at a younger age than women, the men who died were, on average, 4 years younger than women, 78.1 vs 82.1 years old. Relative risk of death in men was 17% higher than women after adjustment for year of admission and age. Conclusion: CAP remains an important cause of hospital mortality in all age groups.
    2018-07-16Artigo científico Acesso aberto Ver mais
  • Sitosterolémia - uma causa rara de uma situação comum
    Publication . Garcia, A.M.; Padeira, G.; Conde, M.; Carvalho, R.; João, A.; Gomes, I.; Bosquet, Lucas G.; Correia, C.; Valongo, C.; Dias, A.; Medeiros, A.; Bourbon, Mafalda; Ferreira, A.C.
    Introdução: A Sitosterolémia (OMIM 210250) é uma doença autossómica recessiva rara do metabolismo dos esteróis vegetais. É causada por mutações nos genes ABCG5 ou ABCG8 (2p21) que codificam as proteínas esterolina 1 e 2 do transportador ABC (ATP-binding cassette), com consequente comprometimento da excreção intestinal e biliar de esteróis e sua acumulação no sangue e tecidos. Clinicamente é caracterizada pela presença de xantomas, níveis elevados de colesterol e aterosclerose prematura, fazendo diagnóstico diferencial com a Hipercolesterolémia Familiar.
    2016-06Documento de conferência Acesso restrito Ver mais
  • The typical presentation of an atypical pathogen during an outbreak of Legionnaires’ disease in Vila Franca de Xira, Portugal, 2014
    Publication . Dias, A.; Cysneiros, A.; Lopes, F.T.; von Amann, B.; Costa, C.; Dionísio, P.; Carvalho, J.; Durão, V.; Carvalho, G.; Paula, F.; Serrado, M.; Nunes, B.; Marques, T.; Froes, F.; Bárbara, C.
    Background: An outbreak of Legionella pneumophila serogroup 1, with 403 cases was identified on the 7th November 2014 in Vila Franca de Xira, Portugal. Outbreak source was the wet cooling system of a local factory. Hospital Pulido Valente was one of the hospitals receiving patients with Legionnaires’ disease (LD). Methods: We describe the clinical findings and diagnostic methods used among the 43 confirmed or probable cases admitted to our department. Results: 60.5% were male, mean age was 56.1 ± 13.5 years and tobacco smoking was the most frequent risk factor (76.7%). All patients had fever, 62.8% ≥39.5 ◦C, 72.1% had chills and myalgia/arthralgia and 62.8% had dry cough. Extra pulmonary symptoms were frequent: confusion and headache occurred in 34.9% and gastrointestinal symptoms in 20.9%. High C-Reactive Protein (55.8% ≥30 mg/dL) and hyponatremia (62.8%) were the laboratorial abnormalities most commonly found. Hypoxemia occurred in 55.8% and hypocapnia in 93%. Urinary Antigen Test (UAT) was positive in 83.7% of the cases. Conclusions: Although not specific, a combination of risk factors, symptoms and laboratory findings can be highly suggestive of LD, even in an outbreak. This should prompt diagnosis
    2017-05Artigo científico Acesso aberto Ver mais