DAN - Relatórios científicos e técnicos
Permanent URI for this collection
Browse
Browsing DAN - Relatórios científicos e técnicos by Author "Alvito, Paula"
Now showing 1 - 4 of 4
Results Per Page
Sort Options
- Deliverable D9.1- report on generic sops- Mandatory, recommended requirements, acceptance criteria, tolerance limits- Deliverable of TDS Project Work PackagePublication . Pité, Marina; Castanheira, Isabel; Oliveira, Luisa; Alvito, Paula
- Human biomonitoring in risk assessment: analysis of the current practice and 1st examples HBM in risk assessments of HBM4EU priority chemicalsPublication . Santonen, T.; Heinälä, M.; Bessems, J.; Buekers, J.; Cornelis, C.; Vermeire, T.; Woutersen, M.; van Engelen, J.; Borges, T.; Rousselle, C.; Ougier, E.; Louro, Henriqueta; Alvito, Paula; Martins, Carla; Assunção, Ricardo; Silva, Maria João Silva; Krul, L.; Pronk, A.; Schaddelee-Scholten, B.; Gonzalez, M.C.; de Alba, M.; Díaz, G.; Castaño, A.; Viegas, S.; Humar-Juric, T.; Kononenko, L.; Abraham, K.; Vinggaard, A.M.In chemicals risk assessment frameworks, the default approach is to assess external intake from different sources of exposure and via different routes of exposure. They are often assessed separately. This approach includes various uncertainties and often overestimates the real uptake since default, conservative estimates are used e.g. for the absorption of the chemical. At the same time, actual (real life) exposure may be underestimated by not taking into account that exposure to a chemical substance may occur from different sources, which may fall under separate legislative frameworks. Examples are triclosan that is used in biocidal products as well as in consumer products and importantly, most if not all chemicals that are produced by workers where at the same time these workers may be exposed as part of the general population. In some cases, other tools to assess exposure via all possible routes may be insufficient; an example is occupational exposure via hand-to-mount exposure, which has been shown to occur for example in the case of many metals, like lead, through contaminated hands. Without biomonitoring, exposure in these cases could become severely underestimated. Human Biomonitoring (HBM) is an important tool to survey the real life body burden – or internal exposure – of humans resulting from ‘total’ exposure to chemicals via different routes (lung, skin, digestive tract) and ‘via’ different legislative frameworks on chemicals. By providing more accurate data on actual body burdens (internal exposure), inclusion of HBM data could improve human health risk assessment for both the general population (exposure via air, consumer products, drinking water and food) as well as for workers (exposure via inhalation and/or skin) separately or as part of the population.
- MYCOMIX - Exploring the toxic effects of mixtures of mycotoxins in infant food and potential health impact: final reportPublication . Alvito, PaulaWithin this final report a detailed description of all tasks of the MYCOMIX project including a global evaluation is enclosed. The present project aims to explore the toxic effects of mixture of mycotoxins in infant food and potential health impact and includes a 1st task on multimycotoxin determination and legislation values, a 2nd on the evaluation of toxic effects of mycotoxin mixtures, a 3rd on bioaccessibility and absorption studies, a 4th on children exposure assessment and a final evaluation, the 5th task, on children´s health and mycotoxin mixtures. All tasks include an initial background and aims, materials and methods, results, deviations/comments, conclusions, references and project indicators. A final description of the total project output indicators is also included.
- Risk Benefit for EU - Partnering to strengthen the risk-benefit assessment within EU using a holistic approach: mid-term reportPublication . Alvito, Paula; Assunção, Ricardo; Fernandes, P.; Boué, Géraldine; Membré, Jeanne-Marie; Pires, Sara; Carvalho, Catarina; Torres, D.RiskBenefit4EU – Partnering to strengthen the risk-benefit assessment within EU using a holistic approach (RB4EU) is a project funded by European Food Safety Authority (EFSA) under Partnering Grants (GP/EFSA/AFSCO/2017/01) and was launched on the 17th January 2018, at a kick-off meeting in the EFSA’s premises, Parma, Italy. With the focus on the capacity building, it aims to develop a strategy to strengthen the EU capacity to assess and integrate food risks and benefits in the areas of microbiological, nutritional and chemical components through the development of a harmonized framework that will be available to EU member states organizations. Within the 1st year of the project, several deliverables and expected outputs were attained, including: two submitted manuscripts, eight communications in national and international conferences, one mid-report, two training activities, one harmonized risk-benefit assessment (RBA) framework on RBA capacity building, one flyer, a project website and one international workshop and the respective abstracts book. In order to answer to specific project and team member’s needs, some adjustments concerning the team composition and the budget allocated to travels and missions were performed, all in agreement with EFSA. RB4EU allowed to gather, for the first time, a multidisciplinary team to develop a capacity building framework on RBA in foods. After the first year of the project, the team and the capacity building framework on RBA in foods are consolidated, allowing to progress on the Portuguese case-study involving data at national level on nutritional, toxicological and microbiological areas. A close collaboration between team members and EFSA have been developed promoting an important support for the project progress.