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DDI - Capítulos (ou partes) de livros

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http://hdl.handle.net/10400.18/21

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Browsing DDI - Capítulos (ou partes) de livros by Author "Ferreira, Eugénia"

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  • Bacterial resistances
    Publication . Manageiro, Vera; Salgueiro, Vanessa; Ferreira, Eugénia; Caniça, Manuela
    Here we review several factors involved in the emergence of antibiotic resistance. They are numerous, and the constant adaptation of microorganisms to the selective pressure exerted by antibiotics is extraordinary. The monitoring systems to assess antibiotic resistance levels and the extent of dissemination were highlighted. In addition, the success of spread of certain bacterial lineages and resistant mechanisms remains sometimes difficult to determine. The need to enlarge research in the area of antibiotic resistance was also stated, not only to better understand the dynamics of dissemination of resistance between different bacteria and different ecosystems, but also to enlarge the pharmaceutical pipeline of antibacterials against multidrug-resistant pathogens. It is manifest the severe consequences of antibiotic resistances to humans, animals and environment, constituting a global public health priority. In consequence, it should be tackled on all fronts in view to the essential concept of “One World-One Medicine-One Health”.
    2017Book part Restricted access Show more
  • Polyclonal KPC-3-producing Enterobacteriaceae in Portugal
    Publication . Manageiro, Vera; Ferreira, Eugénia; Louro, Deolinda; The Antimicrobial Resistance Surveillance Program in Portugal; Caniça, Manuela
    All 6 KPC-3-producing Enterobacteriaceae isolates (5 K. pneumoniae and 1 Enterobacter cloacae), identified among 61 isolates, from different Portuguese health institutions (March 2010 to December 2011) were multidrug resistant, showing susceptibility only to colistin. The blaKPC-3 gene, conferring resistance to carbapenemes, was present alone or in combination with other bla genes: blaSHV-26, blaCTX-M-15, and the ESBL blaSHV-164, here firstly described. The Tn4401-harbouring blaKPC-3 encountered in all isolates, showed a 68 bp deletion upstream of the bla gene. All but two KPC-3-containing plasmids revealed the following types: IncFrepB plus IncFIIs (n=3) and IncFrepB plus IncP (n=1). Dissemination of blaKPC seems to be due to carriage of similar KPC-harbouring plasmids within genetically distinct K. pneumoniae (ST14, ST34, ST59, ST416 and the novel ST960, by MLST) and E. cloacae clinical strains.
    2013Book part Restricted access Show more