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Advisor(s)
Abstract(s)
All 6 KPC-3-producing Enterobacteriaceae isolates (5 K. pneumoniae and 1 Enterobacter cloacae), identified among 61 isolates, from different Portuguese health institutions (March 2010 to December 2011) were multidrug resistant, showing susceptibility only to colistin. The blaKPC-3 gene, conferring resistance to carbapenemes, was present alone or in combination with other bla genes: blaSHV-26, blaCTX-M-15, and the ESBL blaSHV-164, here firstly described. The Tn4401-harbouring blaKPC-3 encountered in all isolates, showed a 68 bp deletion upstream of the bla gene. All but two KPC-3-containing plasmids revealed the following types: IncFrepB plus IncFIIs (n=3) and IncFrepB plus IncP (n=1). Dissemination of blaKPC seems to be due to carriage of similar KPC-harbouring plasmids within genetically distinct K. pneumoniae (ST14, ST34, ST59, ST416 and the novel ST960, by MLST) and E. cloacae clinical strains.
Description
Keywords
Tn4401-KPC-3 IncFrepB Antibiotic Resistance Carbapenemase Resistência aos Antimicrobianos
Pedagogical Context
Citation
Manageiro, V., Ferreira, E., Louro, D., The Antimicrobial Resistance Surveillance Program in Portugal (ARSIP), Caniça, M. 2013. Polyclonal KPC-3-producing Enterobacteriaceae in Portugal, p. 212-216. In Mendez-Vilas A. (ed). Worldwide Research Efforts in the Fighting against Microbial Pathogens: From Basic Research to Technological Developments. Boca Raton: BrownWalker Press.