Clinical Salmonella Typhimurium ST34 with metal tolerance genes and an IncHI2 plasmid carrying oqxAB-aac(6')-Ib-cr from Europe

Campos, Joana; Mourão, Joana; Marçal, Sara; Machado, Jorge; Novais, Carla; Peixe, Luísa; Antunes, Patrícia

http://hdl.handle.net/10400.18/4554

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Fluoroquinolones are critical antibiotics for treating severe Salmonella infections, and the widespread of resistant isolates included in diverse epidemiological scenarios and carrying plasmid-mediated quinolone resistance (PMQR) is a global threat. Among PMQR mechanisms, those encoded by oqxAB and aac(6′)-Ib-cr genes are of special concern as they also confer reduced susceptibility to other antibiotics (oqxAB: chloramphenicol, trimethoprim, olaquindox; aac(6′)-Ib-cr: aminoglycosides) and biocides [oqxAB: quaternary ammonium compounds (QACs)].2,3 Although oqxAB ± aac(6′)-Ib-cr are prevalent and widespread in Asia, where olaquindox is still widely used in animal production, they remain scarce in Europe. Here we describe the molecular characterization of clinical ciprofloxacin-resistant Salmonella enterica Typhimurium with concomitant presence of oqxAB and aac(6′)-Ib-cr recovered for the first time in Europe.

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Anti-Bacterial Agents Child, Preschool Electrophoresis, Gel, Pulsed-Field Europe Feces Gene Order Genotype Humans Infant Metals Microbial Sensitivity Tests Molecular Typing Plasmids Salmonella Infections Salmonella typhimurium Sequence Analysis, DNA Drug Resistance, Bacterial Genes, Bacterial Infecções Gastrointestinais