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Clinical Salmonella Typhimurium ST34 with metal tolerance genes and an IncHI2 plasmid carrying oqxAB-aac(6')-Ib-cr from Europe

2016-03Journal article Restricted access
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dc.contributor.authorCampos, Joana
dc.contributor.authorMourão, Joana
dc.contributor.authorMarçal, Sara
dc.contributor.authorMachado, Jorge
dc.contributor.authorNovais, Carla
dc.contributor.authorPeixe, Luísa
dc.contributor.authorAntunes, Patrícia
dc.date.accessioned2017-03-07T16:49:30Z
dc.date.available2017-03-07T16:49:30Z
dc.date.issued2016-03
dc.description.abstractFluoroquinolones are critical antibiotics for treating severe Salmonella infections, and the widespread of resistant isolates included in diverse epidemiological scenarios and carrying plasmid-mediated quinolone resistance (PMQR) is a global threat. Among PMQR mechanisms, those encoded by oqxAB and aac(6′)-Ib-cr genes are of special concern as they also confer reduced susceptibility to other antibiotics (oqxAB: chloramphenicol, trimethoprim, olaquindox; aac(6′)-Ib-cr: aminoglycosides) and biocides [oqxAB: quaternary ammonium compounds (QACs)].2,3 Although oqxAB ± aac(6′)-Ib-cr are prevalent and widespread in Asia, where olaquindox is still widely used in animal production, they remain scarce in Europe. Here we describe the molecular characterization of clinical ciprofloxacin-resistant Salmonella enterica Typhimurium with concomitant presence of oqxAB and aac(6′)-Ib-cr recovered for the first time in Europe.pt_PT
dc.description.sponsorshipThis work was supported by a research grant from the Fundação para a Ciência e a Tecnologia (grant number UID/Multi/04378/2013). J. Campos and J. Mourão were supported by PhD fellowships from Fundac¸a˜o para a Cieˆncia e a Tecnologia (grant numbers SFRH/BD/93091/2013 and SFRH/ BD/77518/2011, respectively).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Antimicrob Chemother. 2016 Mar;71(3):843-5. doi: 10.1093/jac/dkv409. Epub 2015 Dec 17pt_PT
dc.identifier.doi10.1093/jac/dkv409pt_PT
dc.identifier.issn0305-7453
dc.identifier.urihttp://hdl.handle.net/10400.18/4554
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Press/ British Society for Antimicrobial Chemotherapypt_PT
dc.relation.publisherversionhttps://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dkv409pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAnti-Bacterial Agentspt_PT
dc.subjectChild, Preschoolpt_PT
dc.subjectElectrophoresis, Gel, Pulsed-Fieldpt_PT
dc.subjectEuropept_PT
dc.subjectFecespt_PT
dc.subjectGene Orderpt_PT
dc.subjectGenotypept_PT
dc.subjectHumanspt_PT
dc.subjectInfantpt_PT
dc.subjectMetalspt_PT
dc.subjectMicrobial Sensitivity Testspt_PT
dc.subjectMolecular Typingpt_PT
dc.subjectPlasmidspt_PT
dc.subjectSalmonella Infectionspt_PT
dc.subjectSalmonella typhimuriumpt_PT
dc.subjectSequence Analysis, DNApt_PT
dc.subjectDrug Resistance, Bacterialpt_PT
dc.subjectGenes, Bacterialpt_PT
dc.subjectInfecções Gastrointestinaispt_PT
dc.titleClinical Salmonella Typhimurium ST34 with metal tolerance genes and an IncHI2 plasmid carrying oqxAB-aac(6')-Ib-cr from Europept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04378%2F2013/PT
oaire.citation.endPage845pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage843pt_PT
oaire.citation.titleJournal of Antimicrobial Chemotherapypt_PT
oaire.citation.volume71pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication72797dcd-bef0-4686-8fd4-4ffc88f8cb5b
relation.isProjectOfPublication.latestForDiscovery72797dcd-bef0-4686-8fd4-4ffc88f8cb5b

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