Publication
CYP2D6 and IL-6 c-174G variants in schistosomiasis haematobia
| dc.contributor.author | Cordeiro, R. | |
| dc.contributor.author | Alves, H. | |
| dc.contributor.author | Bordalo, A. | |
| dc.contributor.author | Richter, J | |
| dc.contributor.author | Botelho, M.C. | |
| dc.date.accessioned | 2017-02-13T16:56:09Z | |
| dc.date.available | 2017-02-13T16:56:09Z | |
| dc.date.issued | 2016-11 | |
| dc.description.abstract | AIM: To study the polymorphic variants in CYP2D6 and the C-174G promoter polymorphism of the IL-6 gene on S. haematobium infected patients from an endemic area of Guinea Bissau. BACKGROUND: - Our group has shown that schistosome egg associated catechol estrogens induce tumor-like phenotypes in urothelial cells. These estrogen metabolites might also be the cause of schistosomiasis associated infertility; - The cytochrome P450 (CYP) genes are oxygenases involved in estrogen biosynthesis and metabolism, generation of DNA damaging procarcinogens, and response to anti-estrogen therapies; - IL6 Interleukin-6 (IL-6) is a pleiotropic cytokine expressed in many tissues. These cytokine is largely expressed in female urogenital tract as well as reproduction organs. Very high or very low levels of IL-6 are associated with estrogen metabolism imbalance. | pt_PT |
| dc.description.version | N/A | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/4158 | |
| dc.language.iso | eng | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | pt_PT |
| dc.subject | Schistosomiasis Haematobia | pt_PT |
| dc.subject | Infertility | pt_PT |
| dc.subject | Guinea Bissau | pt_PT |
| dc.title | CYP2D6 and IL-6 c-174G variants in schistosomiasis haematobia | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Póvoa de Varzim, Portugal | pt_PT |
| oaire.citation.title | 5th i3S Annual Meeting, 3-4 november 2016 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |