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CYP2D6 and IL-6 c-174G variants in schistosomiasis haematobia
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Resumo(s)
AIM: To study the polymorphic variants in CYP2D6 and the C-174G promoter polymorphism of the IL-6 gene on S. haematobium infected patients from an endemic
area of Guinea Bissau.
BACKGROUND: - Our group has shown that schistosome egg associated catechol estrogens induce tumor-like phenotypes in urothelial cells. These estrogen metabolites might also be the cause of schistosomiasis associated infertility; - The cytochrome P450 (CYP) genes are oxygenases involved in estrogen biosynthesis and metabolism, generation of DNA damaging procarcinogens, and response to anti-estrogen therapies; - IL6 Interleukin-6 (IL-6) is a pleiotropic cytokine expressed in many tissues. These cytokine is largely expressed in female urogenital tract as well as reproduction organs. Very high or very low levels of IL-6 are associated with estrogen metabolism imbalance.
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Palavras-chave
Schistosomiasis Haematobia Infertility Guinea Bissau