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Age-related dose deposition of particulate matter in human respiratory tract: findings from a birth cross-sectional study in Portugal

2020-10Conference object Open access
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dc.contributor.authorMadureira, Joana
dc.contributor.authorSlezakova, Klara
dc.contributor.authorCosta, Carla
dc.contributor.authorSilva, Ana Inês
dc.contributor.authorMendes, Ana
dc.contributor.authorPereira, Maria do Carmo
dc.contributor.authorTeixeira, João Paulo
dc.date.accessioned2021-03-13T18:16:37Z
dc.date.available2021-03-13T18:16:37Z
dc.date.issued2020-10
dc.description.abstractIndoor air pollution remains a great global concern. Particulate matter (PM), namely ultrafine particles (aerodynamic diameter smaller than 0.1 μm; UFP), is considered as one of the most health-relevant air pollutant for various subpopulations, one of which is children. Knowledge on the specific dose deposition of PM may provide a critical link for better understanding of the relationship between individual exposure and the respective health effects. Mathematical models have proven to be important tools for analysing PM dose deposition in the respiratory tract providing relevant data for health risk assessment, source apportionment of human lung burdens and control strategies purposes. This work aimed to estimate the deposition dose of different PM sizes at different age categories. Inhalation dosimetry estimations were carried out using the multiple-path particle dosimetry model (MPPD, v3.04). Age specific 5-lobe model with uniform expansion was adopted in the present studypt_PT
dc.description.sponsorshipThis work was supported by FCT-FAPESP (FAPESP/19914/2014) and by Base Funding – UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology and Energy – LEPABE – funded by national funds through the FCT/MCTES (PIDDAC). Joana Madureira, Carla Costa and Ana Inês Silva are supported by FCT (SFRH/BPD/115112/2016; SFRH/BPD/96196/2013 and SFRH/BD/145101/2019 grants, respectively).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7480
dc.language.isoengpt_PT
dc.relationLaboratory for Process Engineering, Environment, Biotechnology and Energy
dc.relationEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
dc.relationImpact of transplacental exposure to tobacco smoke in the DNA of newborn. Evaluation of genetic damage and epigenetic changes. Evolution throughout childhood.
dc.relationEffects of in utero exposure to environmental contaminants: an epigenetic approach
dc.subjectParticulate Matterpt_PT
dc.subjectUltrafine Particlespt_PT
dc.subjectChildrenpt_PT
dc.subjectRespiratory Systempt_PT
dc.subjectRespiratory Depositionpt_PT
dc.subjectAr e Saúde Ocupacionalpt_PT
dc.titleAge-related dose deposition of particulate matter in human respiratory tract: findings from a birth cross-sectional study in Portugalpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleLaboratory for Process Engineering, Environment, Biotechnology and Energy
oaire.awardTitleEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
oaire.awardTitleImpact of transplacental exposure to tobacco smoke in the DNA of newborn. Evaluation of genetic damage and epigenetic changes. Evolution throughout childhood.
oaire.awardTitleEffects of in utero exposure to environmental contaminants: an epigenetic approach
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00511%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F115112%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F96196%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F145101%2F2019/PT
oaire.citation.conferencePlaceAthens, Greece (online)pt_PT
oaire.citation.title20th International Symposium on Environmental Pollution and its Impact on Life in the Mediterranean Region, 26-27 October 2020pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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