Contribution to the hazard assessment of benchmark metallic nanomaterials through a set of in vitro genotoxicity assays

Vital, Nádia; El Yamani, Naouale; Pinhão, Mariana; Rúden-Pra, Elise; Louro, Henriqueta; Dušinská, Maria; Silva, Maria João

http://hdl.handle.net/10400.18/5962

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Metallic nanomaterials are among the most commonly applied manufactured nanomaterials (NM). Regardless of the considerable efforts to assess their safety, the presently available data do not allow for general and consistent conclusions. Moreover, the validity of the classical in vitro testing systems for NMs hazard assessment has been questioned and needs confirmation. In the present study, the toxicity of three benchmark metallic NMs, including two insoluble NMs - titanium (NM-100) and cerium (NM-212) dioxides - and soluble silver nanorods/wires (NM-302) was investigated. A panel of in vitro genotoxicity tests that analyze different endpoints was applied and the physico-chemical properties of each NM were considered.