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A predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system

2019-11-25Lecture Restricted access
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dc.contributor.authorVentura, Célia
dc.contributor.authorTeixeira, Sara
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorLourenço, Ana Filipa
dc.contributor.authorFerreira, Paulo J.T.
dc.contributor.authorSilva, Maria João
dc.date.accessioned2020-07-15T15:41:50Z
dc.date.available2020-07-15T15:41:50Z
dc.date.issued2019-11-25
dc.description.abstractCellulose nanofibrils (CNF) have an enormous potential for industrial and biomedical applications, assuming a great economic value. Because other nanofibres, e.g. carbon nanotubes (CNT), have revealed toxicity 1,2, there is a need to comprehensively evaluate the toxic potential of CNF along the value chain, before they enter the market. This project is aimed at a safety evaluation of several CNF comparatively to CNT, in a co-culture of human-derived alveolar epithelial cells and macrophages3. A predictive toxicology approach is used, i.e., the toxicity will be characterized alongside the specific fibre-associated mode of action, including immunotoxicity, genomic and epigenetic effects. The data obtained for two CNF synthesized from Eucalyptus gobulus but using different pre-treatments will be presented. Future work includes the use of omics-based tools adapted to the toxicity assessment of CNF and other NMs that will give some insights on cellular and molecular mechanisms underlying CNF toxicity. The overall results will be used to ensure the safety of these CNF or to allow the modification of toxic CNF in order to reduce the adverse outcomes, thereby complying with the safer-by-design approach.pt_PT
dc.description.sponsorshipProject ToxApp4NanoCELFI (PTDC/SAU-PUB/32587/2017) is funded by the Foundation for Science and Technology (FCT/MCTES), through national funds (PIDDAC).pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7052
dc.language.isoengpt_PT
dc.subjectNanocellulosept_PT
dc.subjectPredictive Toxicologypt_PT
dc.subjectNanotoxicologypt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture systempt_PT
dc.typelecture
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.titleWorkshop 'Nanotoxicology in the context of the safety assessment of nanomaterials', INSA, 25 novembro 2019pt_PT
person.familyNameVentura
person.familyNameLouro
person.familyNameSilva
person.givenNameCélia
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier2056460
person.identifier157627
person.identifier.ciencia-id6116-89BA-C617
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0002-0637-2222
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
rcaap.rightsrestrictedAccesspt_PT
rcaap.typelecturept_PT
relation.isAuthorOfPublicationfa89f42b-12a4-47bd-a4fb-0f65cbc06885
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscoveryfa89f42b-12a4-47bd-a4fb-0f65cbc06885

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