Publication
Upstream open reading frames (uORFs) as translational regulators in human disease
| dc.contributor.author | Fernandes, Rafael | |
| dc.contributor.author | Romão, Luísa | |
| dc.date.accessioned | 2021-05-12T11:25:10Z | |
| dc.date.available | 2021-05-12T11:25:10Z | |
| dc.date.issued | 2020-11-11 | |
| dc.description | Atlas of Science is established to help scientists share, and to bring science to the broader audience. The publication of Layman summaries by academic researchers and access to these summaries for the general public will always be free of charge. | pt_PT |
| dc.description.abstract | The messenger RNA (mRNA) translation process is a key step of gene expression, whose regulation allows the cell to rapidly change protein synthesis in a spatio-temporal manner in response to different stimuli. Translation comprises four steps – initiation, elongation, termination, and ribosome recycling – being initiation the rate-limiting step that is, therefore, prone to a tighter regulation. Among the regulatory elements and factors that can act in this stage, there are the upstream open reading frames (uORFs), which represent coding regions defined by an initiation codon in the 5’ leader sequence [also known as 5’ untranslated region (UTR)] of the mRNAs, in frame with an upstream termination codon or overlapped with the main open reading frame (mORF) that encodes the protein. These cis-acting elements are typically considered to be repressors of downstream translation in basal conditions since they may function as “barriers” to ribosomes, impeding them to reach the mORF. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/7737 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | AoS Nordic AB | pt_PT |
| dc.relation.publisherversion | https://atlasofscience.org/wp-content/uploads/wp-post-to-pdf-enhanced-cache/1/upstream-open-reading-frames-uorfs-as-translational-regulators-in-human-disease.pdf | pt_PT |
| dc.subject | Genetic Disease | pt_PT |
| dc.subject | Non-AUG Upstream Open Reading Frame (uORF) | pt_PT |
| dc.subject | Stress | pt_PT |
| dc.subject | Translational Regulation | pt_PT |
| dc.subject | Translatome | pt_PT |
| dc.subject | uORF | pt_PT |
| dc.subject | uORF-encoded Peptide | pt_PT |
| dc.subject | Genómica Funcional e Estrutural | pt_PT |
| dc.subject | Doenças Genéticas | pt_PT |
| dc.title | Upstream open reading frames (uORFs) as translational regulators in human disease | pt_PT |
| dc.type | other | |
| dspace.entity.type | Publication | |
| oaire.citation.title | Atlas of Science | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | other | pt_PT |
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