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Orientador(es)
Resumo(s)
Bats are increasingly recognized as reservoirs for antimicrobial-resistant bacteria, playing a potential role in the dissemination of resistance genes across species and regions. In this study, 105 bats from 19 species in Portugal were sampled to investigate the presence, antimicrobial resistance, and genetic characteristics of Mammaliicoccus and Staphylococcus isolates. Thirteen Mammaliicoccus lentus and Staphylococcus epidermidis were recovered. Antimicrobial susceptibility testing revealed multidrug resistance in three isolates, with S. epidermidis carrying mph(C), msr(A), and dfrC genes, and M. lentus harboring salB, tet(K), and str. Notably, qacA was detected in S. epidermidis, highlighting its plasmid-associated potential for horizontal gene transfer to more pathogenic bacteria. Heavy metal resistance genes (arsB and cadD) were also identified, suggesting the role of environmental factors in co-selecting antimicrobial resistance. Molecular typing revealed the S. epidermidis strain as ST297, a clone associated with both healthy humans and invasive infections. These findings emphasize the need for monitoring bats as reservoirs of resistance determinants, particularly in the context of zoonotic and environmental health. The presence of mobile genetic elements and plasmids further underscores the potential for the dissemination of resistance. This study reinforces the importance of adopting a One Health approach to mitigate the risks associated with antimicrobial resistance.
Simple Summary: Bats are unique animals that play an important role in ecosystems, but they can also carry bacteria that are resistant to antibiotics. This study examined bats in Portugal to identify bacteria that might pose a risk to humans or other animals. We found two species of bacteria, Mammaliicoccus lentus and Staphylococcus epidermidis, some of which carried antibiotic-resistance genes. These bacteria could potentially spread their resistance to other, more harmful bacteria. Additionally, we found genes that allow the bacteria to resist certain environmental toxins, like heavy metals, which may confer cross-resistance to antibiotics. Understanding how bats carry and spread these bacteria helps scientists and public health officials assess risks and plan measures to prevent the spread of antibiotic-resistant bacteria. This research highlights the importance of monitoring wildlife to protect both human and animal health.
Simple Summary: Bats are unique animals that play an important role in ecosystems, but they can also carry bacteria that are resistant to antibiotics. This study examined bats in Portugal to identify bacteria that might pose a risk to humans or other animals. We found two species of bacteria, Mammaliicoccus lentus and Staphylococcus epidermidis, some of which carried antibiotic-resistance genes. These bacteria could potentially spread their resistance to other, more harmful bacteria. Additionally, we found genes that allow the bacteria to resist certain environmental toxins, like heavy metals, which may confer cross-resistance to antibiotics. Understanding how bats carry and spread these bacteria helps scientists and public health officials assess risks and plan measures to prevent the spread of antibiotic-resistant bacteria. This research highlights the importance of monitoring wildlife to protect both human and animal health.
Descrição
Palavras-chave
Mammaliicoccus lentus Staphylococcus epidermidis Antimicrobial Resistance Bats One Health Zoonotic Potential Resistência aos Antimicrobianos
Contexto Educativo
Citação
Vet Sci. 2025 Apr 1;12(4):322. doi: 10.3390/vetsci12040322
Editora
MDPI