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Bats as Hosts of Antimicrobial-Resistant Mammaliicoccus lentus and Staphylococcus epidermidis with Zoonotic Relevance

2025-04-01Artigo científico Acesso aberto
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dc.contributor.authorSilva, Vanessa
dc.contributor.authorCaniça, Manuela
dc.contributor.authorde la Rivière, Rani
dc.contributor.authorBarros, Paulo
dc.contributor.authorCabral, João Alexandre
dc.contributor.authorPoeta, Patrícia
dc.contributor.authorIgrejas, Gilberto
dc.date.accessioned2026-02-05T16:24:14Z
dc.date.available2026-02-05T16:24:14Z
dc.date.issued2025-04-01
dc.description.abstractBats are increasingly recognized as reservoirs for antimicrobial-resistant bacteria, playing a potential role in the dissemination of resistance genes across species and regions. In this study, 105 bats from 19 species in Portugal were sampled to investigate the presence, antimicrobial resistance, and genetic characteristics of Mammaliicoccus and Staphylococcus isolates. Thirteen Mammaliicoccus lentus and Staphylococcus epidermidis were recovered. Antimicrobial susceptibility testing revealed multidrug resistance in three isolates, with S. epidermidis carrying mph(C), msr(A), and dfrC genes, and M. lentus harboring salB, tet(K), and str. Notably, qacA was detected in S. epidermidis, highlighting its plasmid-associated potential for horizontal gene transfer to more pathogenic bacteria. Heavy metal resistance genes (arsB and cadD) were also identified, suggesting the role of environmental factors in co-selecting antimicrobial resistance. Molecular typing revealed the S. epidermidis strain as ST297, a clone associated with both healthy humans and invasive infections. These findings emphasize the need for monitoring bats as reservoirs of resistance determinants, particularly in the context of zoonotic and environmental health. The presence of mobile genetic elements and plasmids further underscores the potential for the dissemination of resistance. This study reinforces the importance of adopting a One Health approach to mitigate the risks associated with antimicrobial resistance.eng
dc.description.abstractSimple Summary: Bats are unique animals that play an important role in ecosystems, but they can also carry bacteria that are resistant to antibiotics. This study examined bats in Portugal to identify bacteria that might pose a risk to humans or other animals. We found two species of bacteria, Mammaliicoccus lentus and Staphylococcus epidermidis, some of which carried antibiotic-resistance genes. These bacteria could potentially spread their resistance to other, more harmful bacteria. Additionally, we found genes that allow the bacteria to resist certain environmental toxins, like heavy metals, which may confer cross-resistance to antibiotics. Understanding how bats carry and spread these bacteria helps scientists and public health officials assess risks and plan measures to prevent the spread of antibiotic-resistant bacteria. This research highlights the importance of monitoring wildlife to protect both human and animal health.por
dc.description.sponsorshipThis work was supported by the projects UI/00772 and LA/P/0059/2020, funded by the Portuguese Foundation for Science and Technology (FCT). This work received financial support from FCT/MCTES (UIDB/00772/2020, Doi:10.54499/UIDB/00772/2020, UIDB/50006/2020 DOI 10.54499/UIDB/50006/2020, LA/P/0008/2020 DOI 10.54499/LA/P/0008/2020, UIDP/50006/2020 DOI 10.54499/IDP/50006/2020, and UIDB/50006/2020 DOI 10.54499/UIDB/50006/2020).
dc.identifier.citationVet Sci. 2025 Apr 1;12(4):322. doi: 10.3390/vetsci12040322
dc.identifier.doi10.3390/vetsci12040322
dc.identifier.eissn2306-7381
dc.identifier.pmid40284824
dc.identifier.urihttp://hdl.handle.net/10400.18/10822
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationVeterinary and Animal Science Research Centre
dc.relationAssociate Laboratory for Animal and Veterinary Sciences
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relation.hasversionhttps://www.mdpi.com/2306-7381/12/4/322
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMammaliicoccus lentus
dc.subjectStaphylococcus epidermidis
dc.subjectAntimicrobial Resistance
dc.subjectBats
dc.subjectOne Health
dc.subjectZoonotic Potential
dc.subjectResistência aos Antimicrobianos
dc.titleBats as Hosts of Antimicrobial-Resistant Mammaliicoccus lentus and Staphylococcus epidermidis with Zoonotic Relevanceeng
dc.typejournal article
dcterms.referenceshttps://www.mdpi.com/article/10.3390/vetsci12040322/s1
dspace.entity.typePublication
oaire.awardTitleVeterinary and Animal Science Research Centre
oaire.awardTitleAssociate Laboratory for Animal and Veterinary Sciences
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00772%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0059%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0008%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.citation.issue4
oaire.citation.startPage322
oaire.citation.titleVeterinary Sciences
oaire.citation.volume12
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
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