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Prognostic value of human papillomavirus types 16 and 18 DNA physical status in cervical intraepithelial neoplasia

2013-05-27Journal article Restricted access
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dc.contributor.authorGradíssimo, Ana
dc.contributor.authorDelgado, Candida
dc.contributor.authorVerdasca, Nuno
dc.contributor.authorPista, Angela
dc.date.accessioned2013-07-29T15:45:59Z
dc.date.available2013-07-29T15:45:59Z
dc.date.issued2013-05-27
dc.description.abstractThe aim of this work was to assess the value of the physical status of human papillomavirus (HPV) DNA as a disease marker for cervical cancer development in a set of 248 DNA samples previously genotyped as HPV 16 or 18, by calculating the E2/E6 ratio through real-time PCR. There was a significant difference in integration status according to disease grade for both genotypes (p <0.001). Furthermore, especially for HPV 18, determining the DNA physical status could be a useful biomarker in predicting cervical cancer risk development, with a lower E2/E6 ratio clinically associated with the development of a precancerous lesion.por
dc.identifier.citationClin Microbiol Infect. 2013 Oct;19(10):E447-50. doi: 10.1111/1469-0691.12233. Epub 2013 May 9.por
dc.identifier.issn1198-743X
dc.identifier.otherdoi: 10.1111/1469-0691.12233
dc.identifier.urihttp://hdl.handle.net/10400.18/1690
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWiley-Blackwell/ European Society of Clinical Microbiology and Infectious Diseasespor
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/1469-0691.12233/abstractpor
dc.subjectCervical Cancerpor
dc.subjectHuman Papillomavirus 18por
dc.subjectMolecular Markerpor
dc.subjectPhysical Statuspor
dc.subjectRisk Assessmentpor
dc.titlePrognostic value of human papillomavirus types 16 and 18 DNA physical status in cervical intraepithelial neoplasiapor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleClinical Microbiology and Infectionpor
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

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