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Publicação
Prognostic value of human papillomavirus types 16 and 18 DNA physical status in cervical intraepithelial neoplasia
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Orientador(es)
Resumo(s)
The aim of this work was to assess the value of the physical status of human papillomavirus (HPV) DNA as a disease marker for cervical cancer development in a set of 248 DNA samples previously genotyped as HPV 16 or 18, by calculating the E2/E6 ratio through real-time PCR. There was a significant difference in integration status according to disease grade for both genotypes (p <0.001). Furthermore, especially for HPV 18, determining the DNA physical status could be a useful biomarker in predicting cervical cancer risk development, with a lower E2/E6 ratio clinically associated with the development of a precancerous lesion.
Descrição
Palavras-chave
Cervical Cancer Human Papillomavirus 18 Molecular Marker Physical Status Risk Assessment
Contexto Educativo
Citação
Clin Microbiol Infect. 2013 Oct;19(10):E447-50. doi: 10.1111/1469-0691.12233. Epub 2013 May 9.
Editora
Wiley-Blackwell/ European Society of Clinical Microbiology and Infectious Diseases