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- Prognostic value of human papillomavirus types 16 and 18 DNA physical status in cervical intraepithelial neoplasiaPublication . Gradíssimo, Ana; Delgado, Candida; Verdasca, Nuno; Pista, AngelaThe aim of this work was to assess the value of the physical status of human papillomavirus (HPV) DNA as a disease marker for cervical cancer development in a set of 248 DNA samples previously genotyped as HPV 16 or 18, by calculating the E2/E6 ratio through real-time PCR. There was a significant difference in integration status according to disease grade for both genotypes (p <0.001). Furthermore, especially for HPV 18, determining the DNA physical status could be a useful biomarker in predicting cervical cancer risk development, with a lower E2/E6 ratio clinically associated with the development of a precancerous lesion.