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Advisor(s)
Abstract(s)
A Disfunção Tiroideia (DT) nas suas múltiplas formas patológicas, constitui
um importante problema de saúde, geralmente subdiagnosticada, com uma
prevalência estimada de 4-8%. A determinação da concentração de TSH em
combinação com as frações FT4 e FT3 constitui o procedimento laboratorial
principal para obter a informação precisa sobre a função tiroideia (FT).
Neste trabalho, fez-se uma avaliação da FT na população portuguesa, baseada
na amostragem do estudo e_COR, através do doseamento da TSH e da
FT4 em 1673 indivíduos, distribuídos pelas 5 regiões de Portugal continental.
A média destes dois parâmetros e a percentagem de indivíduos com TSH e
FT4 com valores fora do intervalo de referência, foram avaliados de forma a
obter uma estimativa da DT associada a critérios de hipo e hipertiroidismo.
De acordo com estes critérios, obteve-se 7,77% de indivíduos com hipotiroidismo
subclínico (4,00% mulheres e 3,77% homens) e 5,86% com FT4 diminuída
(3,83% mulheres e 2,03% homens). Por outro lado, obteve-se 0,54%
com hipertiroidismo subclínico e 1,44% com FT4 aumentada. Estas percentagens
estão no geral em concordância com a literatura, e a elevada percentagem
de hipotiroidismo subclínico mostra a importância da avaliação da FT
na população pois constitui risco de desenvolvimento de hipotiroidismo clínico
e suas consequências.
Thyroid disease (TD) is an impor tant underdiagnosed health problem with a prevalence of 4-8%. TSH measurements in combination with free T4 and T3 represent the main laborator y testing to get precise information about thyroid status. This study evaluated the thyroid status in a sample of the por tuguese population based on e_COR Study. A total of 1673 individuals, distributed among the five continental regions were tested for TSH and FT4 parameters. Mean values and prevalence were determined for individuals with TSH and FT4 measurements out of the reference range and evaluated according to hypo and hyper thyroidism criteria, estimating the prevalence of TD. A prevalence of 7.77% was found according with criteria of subclinical hypothyroidism (4.0% female and 3.77% male) and 5,86% individuals with FT4 below the lower limit of the reference range (3.83% female e 2.03% male). According to hyper thyroidism criteria, we found 0.54% individuals associated to subclinical hyper thyroidism and 1.44% with FT4 above the upper limit of the reference range. The estimated prevalence is in general in accordance with previous studies. The prevalence associated to subclinical hypothyroidism shows how impor tant is to evaluate thyroid function in the population, since subclinical hypothyroidism is a risk of progression to over t hypothyroidism and its consequences.
Thyroid disease (TD) is an impor tant underdiagnosed health problem with a prevalence of 4-8%. TSH measurements in combination with free T4 and T3 represent the main laborator y testing to get precise information about thyroid status. This study evaluated the thyroid status in a sample of the por tuguese population based on e_COR Study. A total of 1673 individuals, distributed among the five continental regions were tested for TSH and FT4 parameters. Mean values and prevalence were determined for individuals with TSH and FT4 measurements out of the reference range and evaluated according to hypo and hyper thyroidism criteria, estimating the prevalence of TD. A prevalence of 7.77% was found according with criteria of subclinical hypothyroidism (4.0% female and 3.77% male) and 5,86% individuals with FT4 below the lower limit of the reference range (3.83% female e 2.03% male). According to hyper thyroidism criteria, we found 0.54% individuals associated to subclinical hyper thyroidism and 1.44% with FT4 above the upper limit of the reference range. The estimated prevalence is in general in accordance with previous studies. The prevalence associated to subclinical hypothyroidism shows how impor tant is to evaluate thyroid function in the population, since subclinical hypothyroidism is a risk of progression to over t hypothyroidism and its consequences.
Description
Keywords
Função Tiroideia Hipotiroidismo Hipertiroidismo Doenças Metabólicas Portugal
Pedagogical Context
Citation
Boletim Epidemiológico Observações. 2017 setembro-dezembro;6(20):13-16
Publisher
Instituto Nacional de Saúde Doutor Ricardo Jorge, IP
