Repository logo
 
Publication

Effectiveness of long-acting monoclonal antibodies against laboratory-confirmed RSV in children aged < 24 months and hospitalised for severe acute respiratory infection, European pilot study, 2024 to 2025

2025-11-13Journal article Open access
Simple item page
dc.contributor.authorSavulescu, Camelia
dc.contributor.authorGanser, Iris
dc.contributor.authorNicolay, Nathalie
dc.contributor.authorLajot, Adrien
dc.contributor.authorCampos, Sandra
dc.contributor.authorMartínez-Baz, Iván
dc.contributor.authorRodrigues, Ana Paula
dc.contributor.authorVandromme, Mathil
dc.contributor.authorCara-Rodríguez, Marta
dc.contributor.authorEcheverría, Aitziber
dc.contributor.authorGaio, Vânia
dc.contributor.authorParsy, Marie-Pierre
dc.contributor.authorGarrido, Ana Roldan
dc.contributor.authorCastilla, Jesús
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorBacci, Sabrina
dc.contributor.authorRose, Angela Mc
dc.contributor.authorVEBIS hospital network RSV IE group
dc.date.accessioned2026-01-05T15:33:33Z
dc.date.available2026-01-05T15:33:33Z
dc.date.issued2025-11-13
dc.descriptionVEBIS hospital network RSV IE group: Eva Bernaert, Reinout Naesens, Bénédicte Lissoir, Catherine Sion, Sandra Koenig, Xavier Holemans, Bénédicte Delaere, David Tuerlinckx, Marc Bourgeois, Marijke Reynders, Vanessa Verbeke, Catherine Quoidbach, Francesco Genderini, Gabriella Kollar, Nicolas Dauby, Arthur Eggerickx, Arne Witdouck, Deborah De Geyter, Eveline Van Honacker, Lucie Seyler, Siel Daelemans, Koen Magerman, Marlies Blommen, Natasja Detillieu, Veerle Penders, Melanie Delvallee, Pierre Struyven, Isabel Leroux-Roels, Pascal De Waegemaeker, Silke Ternest, Anna Parys, François Dufrasne, Sarah Denayer, Claire Brugerolles, Laurane De Mot, Peace Mpakaniye, Sébastien Fierens, Sven Hanoteaux, Yinthe Dockx, Yves Lafort, Nathalie Bossuyt, Marcos Lozano Alvarez, María Iglesias-Caballero, Gloria Pérez Gimeno, Noa Batalla Rebollo, Irene Pedrosa Corral, Manuel García Cenoz, Guillermo Ezpeleta, Nerea Egüés, Noelia Vera-Punzano, Ana Navascués, Leticia Armendáriz, Ausenda Machado, Miguel Lança, Camila Henriques, Licínia Gomes, Diogo Marques, Madelyn Rojas, Anthony Nardone.
dc.description.abstractWe measured effectiveness of nirsevimab against laboratory-confirmed respiratory syncytial virus (RSV) infection in a test-negative case-control study among children aged < 24 months hospitalised for severe acute respiratory infection in three European countries. The overall effectiveness in the 2024/25 season among 2,201 children was 79% (95% CI: 58 to 89) and 85%, 78% and 69% at < 30, 30-89 and 90-215 days since immunisation. Immunisation was effective for preventing RSV-related hospitalisation in children, but effectiveness by time since immunisation needs monitoring in future seasons.eng
dc.description.sponsorshipThis study was funded by European Centre for Disease Prevention and Control through Vaccine Effectiveness, Burden and Impact Studies (VEBIS) Lot 1 framework contract ECDC/2021/016.
dc.identifier.citationEuro Surveill. 2025 Nov;30(45):2500816. doi: 10.2807/1560-7917.ES.2025.30.45.2500816
dc.identifier.doi10.2807/1560-7917.ES.2025.30.45.2500816
dc.identifier.eissn2590-3322
dc.identifier.issn1560-7917
dc.identifier.pmid41234196
dc.identifier.urihttp://hdl.handle.net/10400.18/10663
dc.language.isoeng
dc.peerreviewedyes
dc.publisherEuropean Centre for Disease Prevention and Control
dc.relationECDC/2021/016
dc.relation.hasversionhttps://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2025.30.45.2500816
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectRSV
dc.subjectMonoclonal Antibodies
dc.subjectNirsevimab
dc.subjectEffectiveness
dc.subjectEurope
dc.subjectDeterminantes da Saúde e da Doença
dc.subjectObservação em Saúde e Vigilância
dc.subjectInfecções Respiratórias
dc.titleEffectiveness of long-acting monoclonal antibodies against laboratory-confirmed RSV in children aged < 24 months and hospitalised for severe acute respiratory infection, European pilot study, 2024 to 2025eng
dc.typejournal article
dcterms.referenceshttps://pmc.ncbi.nlm.nih.gov/articles/instance/12633706/bin/25-00816_SAVULESCU_Supplement.pdf
dspace.entity.typePublication
oaire.citation.issue45
oaire.citation.startPage2500816
oaire.citation.titleEurosurveillance: Europe's journal on infectious disease surveillance, epidemiology, prevention and control
oaire.citation.volume30
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
38-Savulescu et al, 2025.pdf
Size:
332.57 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.03 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DEP - Artigos em revistas internacionais
DDI - Artigos em revistas nacionais
INSA - Artigos em revistas internacionais