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Improved global air quality health index reveals ozone and nitrogen dioxide as main drivers of air-pollution-related acute mortality

2025-10Journal article Restricted access
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dc.contributor.authorHuang, Wenzhong
dc.contributor.authorLi, Tiantian
dc.contributor.authorMasselot, Pierre
dc.contributor.authorXu, Rongbin
dc.contributor.authorGasparrini, Antonio
dc.contributor.authorSera, Francesco
dc.contributor.authorBell, Michelle L.
dc.contributor.authorHashizume, Masahiro
dc.contributor.authorBreitner, Susanne
dc.contributor.authorTong, Shilu
dc.contributor.authorKan, Haidong
dc.contributor.authorYang, Zhengyu
dc.contributor.authorZhang, Yiwen
dc.contributor.authorYu, Wenhua
dc.contributor.authorYu, Pei
dc.contributor.authorZhou, Shuang
dc.contributor.authorSun, Qinghua
dc.contributor.authorZhang, Jingwei
dc.contributor.authorLavigne, Eric
dc.contributor.authorMadureira, Joana
dc.contributor.authorGuo, Yue Leon
dc.contributor.authorGaio, Vânia
dc.contributor.authorLi, Shanshan
dc.contributor.authorGuo, Yuming
dc.contributor.authorMCC Collaborative Research Network
dc.date.accessioned2026-01-16T16:30:56Z
dc.date.available2026-01-16T16:30:56Z
dc.date.issued2025-10
dc.description.abstractAmbient air pollutants are leading contributors to global mortality. Despite the well-established risks, most studies have relied on single-pollutant models in limited regions, leaving the combined effects and individual contributions of pollutants unclear, particularly across countries. Here, we integrate daily mortality and air pollutant (nitrogen dioxide [NO], ozone [O], fine particulate matter, and sulfur dioxide) data from 482 cities in 12 countries/territories from 1998 to 2021 to assess the joint mortality risks and identify the main contributing pollutant through an air quality health index of multi-pollutant constrained groupwise additive models (AQHI-Multi). AQHI-Multi outperformed commonly used air quality indices in capturing the overall mortality risks. O and NO were the leading contributors (accounting for over 70% across countries/territories), with O's share increasing slightly to moderately in most countries/territories. These findings highlight the need for developing air quality indices using advanced multi-pollutant models and the emerging global significance of targeted control of O and NO.eng
dc.description.abstractHighlights - An advanced multi-pollutant model-based air quality health index was developed. -The index outperforms current indices in capturing acute mortality of air pollution. - O3 and NO2 are the main pollutants driving the risk index across regions. - O3 shows rising contributions to the index in most studied countries/territories.eng
dc.description.sponsorshipThis work was supported by the Australian Research Council (DP210102076) and the Australian National Health and Medical Research Council (APP2000581). W.H. was supported by China Scholarship Council funds (202006380055). Z.Y. and W.Y. were supported by a Monash Graduate Scholarship and a Monash International Tuition Scholarship. Y.Z. was supported by a NHMRC e-Asia Joint Research Program grant (GNT2000581). R.X. was supported by VicHealth Postdoctoral Research Fellowships 2022. P.Y. was supported by Monash Faculty of Medicine Nursing and Health Science (FMNHS) Early Career Postdoctoral Fellowships 2023. S.L. was supported by an Emerging Leader Fellowship (GNT2009866) of the Australian National Health and Medical Research Council. Y.G. was supported by a Career Development Fellowship (GNT1163693) and a Leader Fellowship (GNT2008813) of the Australian National Health and Medical Research Council. A.G. was supported by the EU’s Horizon 2020 Project, Exhaustion (grant 820655), and Wellcome-funded project BREATHE (grant no. 308914/Z/23/Z). F.S. was supported by the Medical Research Council, United Kingdom (grant no. MR/R013349/1), the Natural Environment Research Council United Kingdom (grant no. NE/R009384/1), and the EU’s Horizon 2020 project, Exhaustion (grant no. 820655). M.H. was supported by the Japan Science and Technology Agency as part of SICORP, grant number JPMJSC20E4. S.T. was supported by the Science and Technology Commission of Shanghai Municipality (grant no. 18411951600), China.
dc.identifier.citationOne Earth. 2025 Nov;8(11):101488. doi: 10.1016/j.oneear.2025.101488. Epub 2025 Oct 14
dc.identifier.doi10.1016/j.oneear.2025.101488
dc.identifier.eissn2590-3322
dc.identifier.issn2590-3330
dc.identifier.pmid41362416
dc.identifier.urihttp://hdl.handle.net/10400.18/10708
dc.language.isoeng
dc.peerreviewedyes
dc.publisherCell Press
dc.relationExposure to heat and air pollution in EUrope – cardiopulmonary impacts and benefits of mitigation and adaptation
dc.relation.hasversionhttps://linkinghub.elsevier.com/retrieve/pii/S2590332225003148
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAir-Pollution
dc.subjectAir Quality
dc.subjectMortality
dc.subjectDeterminantes da Saúde e da Doença
dc.subjectAvaliação do Risco
dc.titleImproved global air quality health index reveals ozone and nitrogen dioxide as main drivers of air-pollution-related acute mortalityeng
dc.typejournal article
dcterms.referenceshttps://pmc.ncbi.nlm.nih.gov/articles/instance/7618329/bin/EMS209693-supplement-Appendix.pdf
dspace.entity.typePublication
oaire.awardTitleExposure to heat and air pollution in EUrope – cardiopulmonary impacts and benefits of mitigation and adaptation
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/820655/EU
oaire.citation.issue11
oaire.citation.startPage101488
oaire.citation.titleOne Earth
oaire.citation.volume8
oaire.fundingStreamH2020
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
relation.isProjectOfPublication59609b8b-2750-43e0-8fe9-155a4915a572
relation.isProjectOfPublication.latestForDiscovery59609b8b-2750-43e0-8fe9-155a4915a572

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