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Multi-criteria decision analysis to assist biomarker prioritization: developing and testing an approach for the case of COPD - CliniMark WG3 Report - 2019

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dc.contributor.authorPenque, Deborah
dc.date.accessioned2020-06-04T11:21:21Z
dc.date.available2020-06-04T11:21:21Z
dc.date.issued2019-10
dc.descriptionResearch being developing within the scope of a MSc thesis in Biomedical Engineering by Beatriz Norte at Instituto Superior Técnico (Universidade de Lisboa). Supervisor: Mónica Oliveira; Co-supervisors: Deborah Penque and Theo Luiderpt_PT
dc.description.abstractThe identification of protein biomarkers as hallmarks of disease, treatment response or patient’s prognosis holds a great promise for significant advances in personalized medicine. Biomarkers have been also impactful in the field of drug discovery and development. However, despite of the increased number of biomarker studies, only a few of the biomarkers identified have currently implemented into clinical practice. The process of identifying and validating disease specific biomarkers has been quite challenging, requiring large investment of time and resources (Fisler et al 2005; Kearnel et al 2018). To increase the number of clinically validated biomarkers, rather than further increasing the number of biomarker discovery studies, the CliniMARK aimed at creating the best biomarker practice guidelines to establish a coherent biomarker development pipeline from discovery to clinical application in Chronic Obstructive Pulmonary Disease (COPD), as a demonstrator project. CliniMark will gather and classify all known COPD biomarkers and select the appropriate research-grade detection tests. CliniMark will also design technical validation studies and multicenter feasibility studies. (...)pt_PT
dc.description.sponsorshipEuropean Cooperation in Science and Technology action - CA16113pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/6917
dc.language.isoengpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectProtein Biomarkerspt_PT
dc.subjectCOPDpt_PT
dc.subjectChronic Obstructive Pulmonary Diseasept_PT
dc.subjectMulti-criteria Decision Analysispt_PT
dc.subjectMCDApt_PT
dc.subjectProteinspt_PT
dc.subjectBiomarkerspt_PT
dc.subjectGenómica Funcional
dc.subjectGenómica Funcional e Estrutural
dc.titleMulti-criteria decision analysis to assist biomarker prioritization: developing and testing an approach for the case of COPD - CliniMark WG3 Report - 2019pt_PT
dc.typereport
dspace.entity.typePublication
rcaap.rightsclosedAccesspt_PT
rcaap.typereportpt_PT

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