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Publicação
Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
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Orientador(es)
Resumo(s)
We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.
Descrição
Palavras-chave
Amino Acid Sequence Anti-Bacterial Agents Clostridium difficile Enterocolitis, Pseudomembranous Genome, Bacterial Humans Imipenem Microbial Sensitivity Tests Mutation Phylogeny Portugal Whole Genome Sequencing Drug Resistance, Bacterial Ribotyping Infecções Gastrointestinais
Contexto Educativo
Citação
Emerg Infect Dis. 2018 Apr;24(4):741-745. doi: 10.3201/eid2404.170095
Editora
Centers for Disease Control and Prevention