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Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal

2018-04Journal article Open access
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dc.contributor.authorIsidro, Joana
dc.contributor.authorSantos, Andrea
dc.contributor.authorNunes, Alexandra
dc.contributor.authorBorges, Vítor
dc.contributor.authorSilva, Catarina
dc.contributor.authorVieira, Luís
dc.contributor.authorMendes, Aristides L.
dc.contributor.authorSerrano, Mónica
dc.contributor.authorHenriques, Adriano O.
dc.contributor.authorGomes, João Paulo
dc.contributor.authorOleastro, Mónica
dc.date.accessioned2019-03-20T18:11:02Z
dc.date.available2019-03-20T18:11:02Z
dc.date.issued2018-04
dc.description.abstractWe describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.pt_PT
dc.description.sponsorshipThis work was supported by the National Institute of Health Dr. Ricardo Jorge (grant no. 2016DDI1284). We also acknowledge grant Pest-C/EQB/LA0006/2011 from Fundação para a Ciência e a Tecnologia (FCT; http://www.fct.pt) and program Investigador FCT (IF/00268/2013/CP1173/CT0006 to M.S.). A.L.M. was supported by a PhD fellowship (PD/BD/105738/2014) from the FCT.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEmerg Infect Dis. 2018 Apr;24(4):741-745. doi: 10.3201/eid2404.170095pt_PT
dc.identifier.doi10.3201/eid2404.170095pt_PT
dc.identifier.issn1080-6040
dc.identifier.urihttp://hdl.handle.net/10400.18/6256
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCenters for Disease Control and Preventionpt_PT
dc.relationCharacterization of Clostridium Difficile: a genetic and biochemistry approach
dc.relation.publisherversionhttps://wwwnc.cdc.gov/eid/article/24/4/17-0095_articlept_PT
dc.subjectAmino Acid Sequencept_PT
dc.subjectAnti-Bacterial Agentspt_PT
dc.subjectClostridium difficilept_PT
dc.subjectEnterocolitis, Pseudomembranouspt_PT
dc.subjectGenome, Bacterialpt_PT
dc.subjectHumanspt_PT
dc.subjectImipenempt_PT
dc.subjectMicrobial Sensitivity Testspt_PT
dc.subjectMutationpt_PT
dc.subjectPhylogenypt_PT
dc.subjectPortugalpt_PT
dc.subjectWhole Genome Sequencingpt_PT
dc.subjectDrug Resistance, Bacterialpt_PT
dc.subjectRibotypingpt_PT
dc.subjectInfecções Gastrointestinaispt_PT
dc.titleImipenem Resistance in Clostridium difficile Ribotype 017, Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCharacterization of Clostridium Difficile: a genetic and biochemistry approach
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F105738%2F2014/PT
oaire.citation.endPage745pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage741pt_PT
oaire.citation.titleEmerging Infectious Diseasept_PT
oaire.citation.volume24pt_PT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication6b1b9a19-262e-4e87-8d79-6925673471e6
relation.isProjectOfPublication.latestForDiscovery6b1b9a19-262e-4e87-8d79-6925673471e6

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