Publication
Signal transduction pathways regulating alternative splicing of tumour-related RAC1b
| dc.contributor.author | Gonçalves, Vânia | |
| dc.contributor.author | Matos, Paulo | |
| dc.contributor.author | Henriques, Andreia | |
| dc.contributor.author | Pereira, Joana | |
| dc.contributor.author | Jordan, Peter | |
| dc.date.accessioned | 2018-03-13T15:31:19Z | |
| dc.date.available | 2018-03-13T15:31:19Z | |
| dc.date.issued | 2017-10 | |
| dc.description.abstract | The expression of most genes in the human genome can yield >1 transcript through the process of alternative splicing of pre-messenger RNA. Alternatively spliced transcripts significantly increase the complexity of human gene products because they either influence transcript degradation levels or encode functional protein variants that differ in specific domains. Even with cutting-edge transcriptomic approaches, it has been extremely challenging to understand or predict the complex splicing patterns observed in tissues or in diseases such as cancer; therefore, a better understanding of how cells are able to regulate alternative splicing is required. | pt_PT |
| dc.description.sponsorship | This work was supported by the Fundação para a Ciência e Tecnologia through a centre grant (UID/MULTI/04046/2013) to BioISI, and by the Portuguese association Maratona da Saúde - Cancro 2014. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | EMJ Oncol. 2017;51[1]:45-46. Abstract review No. AR5 | pt_PT |
| dc.identifier.issn | ISSN-2054-619X | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/5395 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | no | pt_PT |
| dc.publisher | European Medical Journal | pt_PT |
| dc.relation.publisherversion | http://www.emjreviews.com/oncology/abstract/signal-transduction-pathways-regulating-alternative-splicing-of-tumour-related-rac1b/ | pt_PT |
| dc.subject | Signalling Pathways | pt_PT |
| dc.subject | Alternative Splicing | pt_PT |
| dc.subject | RAC1b | pt_PT |
| dc.subject | Splicing Alternativo | pt_PT |
| dc.subject | Vias de Transdução de Sinal e Patologias Associadas | pt_PT |
| dc.subject | Cancro Coloretal | pt_PT |
| dc.title | Signal transduction pathways regulating alternative splicing of tumour-related RAC1b | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04046%2F2013/PT | |
| oaire.citation.endPage | 46 | pt_PT |
| oaire.citation.issue | [1] | pt_PT |
| oaire.citation.startPage | 45 | pt_PT |
| oaire.citation.title | European Medical Journal Oncology | pt_PT |
| oaire.citation.volume | 5 | pt_PT |
| oaire.fundingStream | 5876 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isProjectOfPublication | dc84f768-e6f2-4eea-b294-6c8ebbd1a156 | |
| relation.isProjectOfPublication.latestForDiscovery | dc84f768-e6f2-4eea-b294-6c8ebbd1a156 |