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Publicação
Signal transduction pathways regulating alternative splicing of tumour-related RAC1b
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Orientador(es)
Resumo(s)
The expression of most genes in the human
genome can yield >1 transcript through the
process of alternative splicing of pre-messenger
RNA. Alternatively spliced transcripts significantly
increase the complexity of human gene products
because they either influence transcript
degradation levels or encode functional protein
variants that differ in specific domains.
Even with cutting-edge transcriptomic approaches, it has
been extremely challenging to understand or
predict the complex splicing patterns observed in
tissues or in diseases such as cancer; therefore,
a better understanding of how cells are able to
regulate alternative splicing is required.
Descrição
Palavras-chave
Signalling Pathways Alternative Splicing RAC1b Splicing Alternativo Vias de Transdução de Sinal e Patologias Associadas Cancro Coloretal
Contexto Educativo
Citação
EMJ Oncol. 2017;51[1]:45-46. Abstract review No. AR5