Schistosoma mansoni infection associated infertility

Botelho, Mónica

Publication

Schistosoma mansoni infection associated infertility

2016-06-17Lecture

dc.contributor.author	Botelho, Mónica
dc.date.accessioned	2017-03-02T12:04:13Z
dc.date.available	2017-03-02T12:04:13Z
dc.date.issued	2016-06-17
dc.description.abstract	Schistosomiasis is a neglected tropical disease, endemic in 76 countries, that afflicts more than 240 million people. The impact of schistosomiasis on infertility may be underestimated according to recent literature. Extracts of Schistosoma haematobium include estrogen-like metabolites termed catechol-estrogens that down regulate estrogen receptors alpha and beta in estrogen responsive cells. In addition, schistosome derived catechol-estrogens induce genotoxicity that result in estrogen-DNA adducts and cause hormonal imbalance. We now hypothesize the induction of infertility in individuals infected with S. mansoni also through an hormonal imbalance. The aim of this study was to study infertility in mice infected with S. mansoni. Female mice infected with Schistosoma mansoni and noninfected female controls, male mice infected with S. mansoni and noninfected male controls were mated during 8 months. Gestational length and, number of pupps were studied. Animals were euthanized and their ovaries, uterus and testes were examined histopathologically. Infected females had shorted gestational length than controls. Births of infected females were not synchronous as in controls. The number of pupps was decreased in infected females in comparison to controls. Ovaries, uterus and testes of infected mice showed definite structural damage. No ova, worms or specific granulomata were detected in infected mice in organs other than liver and spleen. To our knowledge this is the first study addressing S. mansoni infection associated infertility. It is concluded that schistosomiasis has an important metabolic effect leading to reproduction disorder in infected animals. These results together with histopathological findings with absence of egg in all examined ovaries, uterus and testicular sections emphasize the possible role of hormonal imbalance in the pathogenesis of such lesions. The changes observed could be due to catechol-estrogens associated with schistosomiasis.	pt_PT
dc.description.version	N/A	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.18/4390
dc.language.iso	eng	pt_PT
dc.publisher	Instituto Nacional de Saúde Doutor Ricardo Jorge, IP	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/	pt_PT
dc.subject	Schistosoma mansoni	pt_PT
dc.subject	Infertility	pt_PT
dc.subject	Schistosomiasis	pt_PT
dc.subject	Tropical Disease	pt_PT
dc.title	Schistosoma mansoni infection associated infertility	pt_PT
dc.type	lecture
dspace.entity.type	Publication
oaire.citation.conferencePlace	Lisboa, Portugal	pt_PT
oaire.citation.title	Palestras do DPSPDNT, INSA, 17 junho 2016	pt_PT
rcaap.rights	openAccess	pt_PT
rcaap.type	lecture	pt_PT