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Evaluation of Morinda citrofolia chemopreventive effects against patulin

2016-06Conference object Restricted access
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dc.contributor.authorTorrejais, Joana
dc.contributor.authorGuidoti, David
dc.contributor.authorPinhão, Mariana
dc.contributor.authorSilva, Maria João
dc.date.accessioned2017-03-15T11:27:25Z
dc.date.available2017-03-15T11:27:25Z
dc.date.issued2016-06
dc.description.abstractMorinda citrofolia (noni), is a tropical plant that has been studied for its content of phenolic compounds, which display antioxidant properties. Although many authors have shown that fruit pulp is the part of noni plant richer in those compounds, all parts (leaves, rods and stem) are being used as traditional medicines in tropical countries. Patulin (PAT) is one of the most common mycotoxins, frequently found in spoiled fruits (apples), moldy feeds and stored cheese, representing a serious health concern because of its genotoxic, carcinogenic, neurotoxic and teratogenic effects that are mainly mediated by the formation of reactive oxygen species. Therefore, it is of utmost importance to identify bioactive natural compounds able to reduce the deleterious effects of patulin and other mycotoxins, in order to protect the human health. This is a particularly relevant concern in tropical regions where food contamination with mycotoxins has a strong negative impact on human health. On the other hand, ethyl methanesulfonate (EMS) is a model alkylating agent inducing mostly point mutations. This work intended to explore the chemopreventive properties of a noni fruit hexanic extract prepared in Brazil.pt_PT
dc.description.sponsorshipThis work was co-funded through UID/BIM/00009/2013 (ToxOmics), da Fundação para a Ciência e Tecnologia, Portugal.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/4655
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectBioactive compoundspt_PT
dc.subjectChemopreventionpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleEvaluation of Morinda citrofolia chemopreventive effects against patulinpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F00009%2F2013/PT
oaire.citation.conferencePlacePorto, Portugalpt_PT
oaire.citation.title3rd International Conference on Occupational & Environmental Toxicology (ICOETox)/ 3rd Ibero-American Meeting on Toxicology and Environmental Health (IBAMTox), 21-23 june 2016pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublicatione9cc9728-4f09-4e3a-b30d-53d4429986fb
relation.isProjectOfPublication.latestForDiscoverye9cc9728-4f09-4e3a-b30d-53d4429986fb

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